HtrC

• Description: similar to quality control membrane serine protease HtrA
  
  

Gene name	htrC
Synonyms	yycK, yyxA
Essential	no
Product	putative quality control membrane protease
Function	unknown
Gene expression levels in SubtiExpress: htrC
MW, pI	42 kDa, 5.315
Gene length, protein length	1200 bp, 400 aa
Immediate neighbours	yyzO, walJ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

proteolysis, sporulation proteins, membrane proteins

This gene is a member of the following regulons

SigG regulon

The gene

Basic information

• Locus tag: BSU40360

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: peptidase S1B family (according to Swiss-Prot)

• Paralogous protein(s): HtrA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactors:

• Effectors of protein activity:

• Interactions:
  • HtrC is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of interactions PubMed
  • HtrC-YpeB, for proteolysis of YpeB during germination PubMed

• Localization: cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P39668

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon:
  • walR-walK-yycH-yycI-walJ-htrC PubMed
  • yyxA PubMed

• Expression browser: htrC PubMed

• Sigma factor: for htrC: SigG PubMed

• Regulation:
  • expressed during vegetative growth, repressed during stationary phase PubMed
  • htrC transcript expressed during sporulation PubMed
  • walR-walK-yycH-yycI-walJ-htrC is induced upon deletion of htrA and htrB PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Tim Clausen, Markus Kaiser, Robert Huber, Michael Ehrmann
HTRA proteases: regulated proteolysis in protein quality control.
Nat Rev Mol Cell Biol: 2011, 12(3);152-62
[PubMed:21326199] [WorldCat.org] [DOI] (I p)