CtaD

• Description: cytochrome-c oxidase (subunit I)
  
  

Gene name	ctaD
Synonyms
Essential	no
Product	cytochrome-c oxidase (subunit I)
Function	respiration
Gene expression levels in SubtiExpress: ctaD
MW, pI	68 kDa, 6.985
Gene length, protein length	1866 bp, 622 aa
Immediate neighbours	ctaC, ctaE
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

respiration, membrane proteins

This gene is a member of the following regulons

Abh regulon, AbrB regulon, ResD regulon, Efp-dependent proteins

The gene

Basic information

• Locus tag: BSU14900

Phenotypes of a mutant

essential according to PubMed, non-essential according to PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 4 ferrocytochrome c + O₂ + 4 H⁺ = 4 ferricytochrome c + 2 H₂O (according to Swiss-Prot)

• Protein family: heme-copper respiratory oxidase family (according to Swiss-Prot)

• Paralogous protein(s): QoxB

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s): 2 heme A molecules, Cu(B) PubMed

• Effectors of protein activity:

• Interactions:

• Localization:
  • cell membrane (according to Swiss-Prot)

Database entries

• Structure:

• UniProt: P24010

• KEGG entry: [3]

• E.C. number: 1.9.3.1

Expression and regulation

• • Operon: ctaB-ctaC-ctaD-ctaE-ctaF-ctaG PubMed

• Expression browser: ctaD PubMed

• Sigma factor:

• Regulation:
  • expressed under anaerobic conditions (ResD) PubMed

• Regulatory mechanism:
  • ResD: transcription activation PubMed
  • Abh and AbrB: synergistic transcription repression PubMed

• Additional information:
  • translation is likely to require Efp due to the presence of several consecutive proline residues PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: