Fin

• Description:
  • suppressor of recU mutations, participates in the stabilization and or processing of holliday junction intermediates PubMed
    
  • alternative description: antagonist to SigF, required for the switch from SigF- to SigG-dependent gene expression in the forespore PubMed
    
    

Gene name	subA
Synonyms	yabK
Essential	no
Product	unknown
Function	homologous recombination
Gene expression levels in SubtiExpress: fin
MW, pI	8 kDa, 5.192
Gene length, protein length	228 bp, 76 aa
Immediate neighbours	spoVC, mfd
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

DNA repair/ recombination, sigma factors and their control, sporulation proteins

The gene

Basic information

• Locus tag: BSU00540

Phenotypes of a mutant

sporulation defect (50-fold reduction of viable spore count) and arrest after engulfment PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • SigF-Fin (probably) PubMed

• Localization: localizes diffusely within the forespore compartment of sporangia at both early and late stages of sporulation, cytosolic protein PubMed

Database entries

• Structure:

• UniProt: P37553

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: fin PubMed

• Sigma factor: SigF PubMed, SigG PubMed

• Regulation: expressed in two waves in the forespore (after two hours (SigF) and three hours (SigG) after the onset of sporulation) PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Begoña Carrasco, M Castillo Cozar, Rudi Lurz, Juan C Alonso, Silvia Ayora
Genetic recombination in Bacillus subtilis 168: contribution of Holliday junction processing functions in chromosome segregation.
J Bacteriol: 2004, 186(17);5557-66
[PubMed:15317759] [WorldCat.org] [DOI] (P p)

B Carrasco, S Fernández, K Asai, N Ogasawara, J C Alonso
Effect of the recU suppressors sms and subA on DNA repair and homologous recombination in Bacillus subtilis.
Mol Genet Genomics: 2002, 266(5);899-906
[PubMed:11810266] [WorldCat.org] [DOI] (P p)

Additional publications: PubMed