NtdC

• Description: NAD-dependent glucose-6-phosphate dehydrogenase
  
  

Gene name	ntdC
Synonyms	yhjJ
Essential	no
Product	NAD-dependent glucose-6-phosphate dehydrogenase
Function	synthesis of the antibiotic kanosamine
Gene expression levels in SubtiExpress: ntdC
MW, pI	39 kDa, 6.227
Gene length, protein length	1050 bp, 350 aa
Immediate neighbours	glcP, ntdB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

NtdR regulon

The gene

Basic information

• Locus tag: BSU10530

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • glucose-6-phosphate + NAD --> 3-oxo-d-glucose-6-phosphate + NADH(2) PubMed

• Protein family: gfo/idh/mocA family (according to Swiss-Prot)

• Paralogous protein(s): YfiI, YrbE, YteT, YulF, IolW, IolX, IolG

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):
  • NAD(+) PubMed

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O07564

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ntdA-ntdB-ntdC-glcP PubMed

• Expression browser: ntdC PubMed

• Sigma factor: SigA PubMed

• Regulation: induced by 3,3'-neotrehalosadiamine (NtdR) PubMed

• Regulatory mechanism: NtdR: positive regulator PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Takashi Inaoka, Kozo Ochi
Activation of dormant secondary metabolism neotrehalosadiamine synthesis by an RNA polymerase mutation in Bacillus subtilis.
Biosci Biotechnol Biochem: 2011, 75(4);618-23
[PubMed:21512256] [WorldCat.org] [DOI] (I p)