AlbA

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  • Description: radical S-adenosylmethionine enzyme, antilisterial bacteriocin (subtilosin) production

Gene name albA
Synonyms ywiA
Essential no
Product radical S-adenosylmethionine enzyme
Function antilisterial bacteriocin (subtilosin) production
MW, pI 51 kDa, 6.195
Gene length, protein length 1344 bp, 448 aa
Immediate neighbours sboX, albB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AlbA context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

AbrB regulon, ResD regulon, Rok regulon

The gene

Basic information

  • Locus tag: BSU37370

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • catalyzes thioether bond formation in subtilosin A PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): contains two [4Fe-4S] clusters PubMed
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Leif Flühe, Thomas A Knappe, Michael J Gattner, Antje Schäfer, Olaf Burghaus, Uwe Linne, Mohamed A Marahiel
The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A.
Nat Chem Biol: 2012, 8(4);350-7
[PubMed:22366720] [WorldCat.org] [DOI] (I e)

Mark A Strauch, Benjamin G Bobay, John Cavanagh, Fude Yao, Angelo Wilson, Yoann Le Breton
Abh and AbrB control of Bacillus subtilis antimicrobial gene expression.
J Bacteriol: 2007, 189(21);7720-32
[PubMed:17720793] [WorldCat.org] [DOI] (P p)

Paul D Straight, Michael A Fischbach, Christopher T Walsh, David Z Rudner, Roberto Kolter
A singular enzymatic megacomplex from Bacillus subtilis.
Proc Natl Acad Sci U S A: 2007, 104(1);305-10
[PubMed:17190806] [WorldCat.org] [DOI] (P p)

Mark Albano, Wiep Klaas Smits, Linh T Y Ho, Barbara Kraigher, Ines Mandic-Mulec, Oscar P Kuipers, David Dubnau
The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions.
J Bacteriol: 2005, 187(6);2010-9
[PubMed:15743949] [WorldCat.org] [DOI] (P p)

M M Nakano, G Zheng, P Zuber
Dual control of sbo-alb operon expression by the Spo0 and ResDE systems of signal transduction under anaerobic conditions in Bacillus subtilis.
J Bacteriol: 2000, 182(11);3274-7
[PubMed:10809710] [WorldCat.org] [DOI] (P p)

G Zheng, R Hehn, P Zuber
Mutational analysis of the sbo-alb locus of Bacillus subtilis: identification of genes required for subtilosin production and immunity.
J Bacteriol: 2000, 182(11);3266-73
[PubMed:10809709] [WorldCat.org] [DOI] (P p)

G Zheng, L Z Yan, J C Vederas, P Zuber
Genes of the sbo-alb locus of Bacillus subtilis are required for production of the antilisterial bacteriocin subtilosin.
J Bacteriol: 1999, 181(23);7346-55
[PubMed:10572140] [WorldCat.org] [DOI] (P p)