ParA

From SubtiWiki
Revision as of 14:24, 1 April 2011 by Heilers (talk | contribs) (Basic information/ Evolution)
Jump to: navigation, search
  • Description: ATPase, centromere-like function involved in forespore chromosome partitioning / negative regulation of sporulation initiation

Gene name soj
Synonyms spo0JA
Essential no
Product negative regulator of sporulation initiation
Function forespore chromosome partitioning /
negative regulation of sporulation initiation
MW, pI 27 kDa, 4.903
Gene length, protein length 759 bp, 253 aa
Immediate neighbours spo0J, yyaB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Soj context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

DNA condensation/ segregation, sporulation/ other, membrane proteins

This gene is a member of the following regulons

Spo0A regulon

The gene

Basic information

  • Locus tag: BSU40970

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Protein family: parA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
    • Spo0J inhibits Soj dimerization and concomitant DNA-binding activity by stimulating Soj ATPase activity PubMed


  • Localization:
    • polar/ septal at the cell membrane PubMed
    • polar localization depends on the proton motive force PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • repressed under conditions that trigger sporulation (Spo0A) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Tsutomu Katayama, Shogo Ozaki, Kenji Keyamura, Kazuyuki Fujimitsu
Regulation of the replication cycle: conserved and diverse regulatory systems for DnaA and oriC.
Nat Rev Microbiol: 2010, 8(3);163-70
[PubMed:20157337] [WorldCat.org] [DOI] (I p)

Original publications