RocR

• Description: transcriptional activator of arginine utilization operons
  
  

Gene name	rocR
Synonyms
Essential	no
Product	transcriptional regulator
Function	transcriptional activator of arginine utilization operons
MW, pI	52.6 kDa, 6.08
Gene length, protein length	1383 bp, 461 amino acids
Immediate neighbours	rocD, yyxA
Gene sequence (+200bp)	Protein sequence
Genetic context File:GenE context.gif

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: transcription activation at SigL-dependent promoters of rocABC, rocDEF, and rocG

• Protein family: Sigma-54 interacting transcription activator

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:
  • Sigma-54 factor interaction domain (143–372)
  • 2x nucleotid-binding domain (171–178),(233–242)
  • HTH motif (434–453)

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: RocR-SigL

• Localization:

Database entries

• Structure:

• Swiss prot entry: [3]

• KEGG entry: [4]

Expression and regulation

• Operon: rocR

• Sigma factor: SigA PubMed

• Regulation: autoregulation by RocR PubMed

• Regulatory mechanism: autorepression

• Additional information:

Labs working on this gene/protein

Michel Debarbouille, Pasteur Institute, Paris, France Homepage

References

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed