RNA degradosome

Components of the RNA degradosome

• RNase Y: ssRNA endonuclease
• RNase J1: 5'-3' exonuclease, does also have endonuclease activity
• polynucleotide phosphorylase: 3'-5' exonuclease
• RNase J2: ssRNA endonuclease, may also have exonuclease activity
• CshA
• enolase
• phosphofructokinase

Related pages

• RNases
• DEAD-box RNA helicases

Reviews on the B. subtilis RNA degradosome

Sylvain Durand, Ciaran Condon
RNases and Helicases in Gram-Positive Bacteria.
Microbiol Spectr: 2018, 6(2);
[PubMed:29651979] [WorldCat.org] [DOI] (I p)

Martin Lehnik-Habrink, Marc Schaffer, Ulrike Mäder, Christine Diethmaier, Christina Herzberg, Jörg Stülke
RNA processing in Bacillus subtilis: identification of targets of the essential RNase Y.
Mol Microbiol: 2011, 81(6);1459-73
[PubMed:21815947] [WorldCat.org] [DOI] (I p)

Original publications on the B. subtilis RNA degradosome

Inam Ul Haq, Peter Müller, Sabine Brantl
A comprehensive study of the interactions in the B. subtilis degradosome with special emphasis on the role of the small proteins SR1P and SR7P.
Mol Microbiol: 2024, 121(1);40-52
[PubMed:37994189] [WorldCat.org] [DOI] (I p)

Nora Cascante-Estepa, Katrin Gunka, Jörg Stülke
##Title##
Front Microbiol: 2016, 7;1492
[PubMed:27708634] [WorldCat.org] [DOI] (P e)

Martin Lehnik-Habrink, Henrike Pförtner, Leonie Rempeters, Nico Pietack, Christina Herzberg, Jörg Stülke
The RNA degradosome in Bacillus subtilis: identification of CshA as the major RNA helicase in the multiprotein complex.
Mol Microbiol: 2010, 77(4);958-71
[PubMed:20572937] [WorldCat.org] [DOI] (I p)

Fabian M Commichau, Fabian M Rothe, Christina Herzberg, Eva Wagner, Daniel Hellwig, Martin Lehnik-Habrink, Elke Hammer, Uwe Völker, Jörg Stülke
Novel activities of glycolytic enzymes in Bacillus subtilis: interactions with essential proteins involved in mRNA processing.
Mol Cell Proteomics: 2009, 8(6);1350-60
[PubMed:19193632] [WorldCat.org] [DOI] (I p)

General reviews on the RNA degradosome

Peter Redder
Molecular and genetic interactions of the RNA degradation machineries in Firmicute bacteria.
Wiley Interdiscip Rev RNA: 2018, 9(2);
[PubMed:29314657] [WorldCat.org] [DOI] (I p)

Peter Redder, Stéphane Hausmann, Vanessa Khemici, Haleh Yasrebi, Patrick Linder
Bacterial versatility requires DEAD-box RNA helicases.
FEMS Microbiol Rev: 2015, 39(3);392-412
[PubMed:25907111] [WorldCat.org] [DOI] (I p)

Monica P Hui, Patricia L Foley, Joel G Belasco
Messenger RNA degradation in bacterial cells.
Annu Rev Genet: 2014, 48;537-59
[PubMed:25292357] [WorldCat.org] [DOI] (I p)

Zbigniew Dominski, Agamemnon J Carpousis, Béatrice Clouet-d'Orval
Emergence of the β-CASP ribonucleases: highly conserved and ubiquitous metallo-enzymes involved in messenger RNA maturation and degradation.
Biochim Biophys Acta: 2013, 1829(6-7);532-51
[PubMed:23403287] [WorldCat.org] [DOI] (P p)

Maria W Górna, Agamemnon J Carpousis, Ben F Luisi
From conformational chaos to robust regulation: the structure and function of the multi-enzyme RNA degradosome.
Q Rev Biophys: 2012, 45(2);105-45
[PubMed:22169164] [WorldCat.org] [DOI] (I p)

David H Bechhofer
Bacillus subtilis mRNA decay: new parts in the toolkit.
Wiley Interdiscip Rev RNA: 2011, 2(3);387-94
[PubMed:21957024] [WorldCat.org] [DOI] (I p)

Vladimir R Kaberdin, Sue Lin-Chao
Unraveling new roles for minor components of the E. coli RNA degradosome.
RNA Biol: 2009, 6(4);402-5
[PubMed:19667755] [WorldCat.org] [DOI] (I p)

Agamemnon J Carpousis
The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E.
Annu Rev Microbiol: 2007, 61;71-87
[PubMed:17447862] [WorldCat.org] [DOI] (P p)

Maria Jose Marcaida, Mark A DePristo, Vidya Chandran, Agamemnon J Carpousis, Ben F Luisi
The RNA degradosome: life in the fast lane of adaptive molecular evolution.
Trends Biochem Sci: 2006, 31(7);359-65
[PubMed:16766188] [WorldCat.org] [DOI] (P p)

A J Carpousis
The Escherichia coli RNA degradosome: structure, function and relationship in other ribonucleolytic multienzyme complexes.
Biochem Soc Trans: 2002, 30(2);150-5
[PubMed:12035760] [WorldCat.org] (P p)