PAS domain

Introduction

The PAS domain is a protein domain contained in many signaling proteins where it functions as a signal sensor. PAS domains are found in a large number of organisms from bacteria to humans. The PAS domain was named after the three proteins in which it was first discovered:

• Per – period circadian protein
• Arnt – aryl hydrocarbon receptor nuclear translocator protein
• Sim – single-minded protein

B. subtilis proteins containing a PAS domain

• BkdR
• CitS
• DctS
• DgcW
• GdpP
• KinA
• KinC
• KinE
• MalK
• PhoR
• ResE
• RocR
• RsbP
• WalK
• YtvA

Related SubtiWiki pages

• Two-component systems

Important reviews

Jiawei Xing, Vadim M Gumerov, Igor B Zhulin
Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor.
Sci Adv: 2023, 9(35);eadi4517
[PubMed:37647406] [WorldCat.org] [DOI] (I p)

Jonathan T Henry, Sean Crosson
Ligand-binding PAS domains in a genomic, cellular, and structural context.
Annu Rev Microbiol: 2011, 65;261-86
[PubMed:21663441] [WorldCat.org] [DOI] (I p)

Barry L Taylor
Aer on the inside looking out: paradigm for a PAS-HAMP role in sensing oxygen, redox and energy.
Mol Microbiol: 2007, 65(6);1415-24
[PubMed:17824925] [WorldCat.org] [DOI] (P p)

Paul J A Erbel, Paul B Card, Ozgur Karakuzu, Richard K Bruick, Kevin H Gardner
Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor.
Proc Natl Acad Sci U S A: 2003, 100(26);15504-9
[PubMed:14668441] [WorldCat.org] [DOI] (P p)

B L Taylor, I B Zhulin
PAS domains: internal sensors of oxygen, redox potential, and light.
Microbiol Mol Biol Rev: 1999, 63(2);479-506
[PubMed:10357859] [WorldCat.org] [DOI] (P p)