Difference between revisions of "BmrD"

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=== Additional information===
 
=== Additional information===
 
  
 
=The protein=
 
=The protein=
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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:'''  
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* '''Operon:''' ''[[bmrB]]-[[bmrC]]-[[bmrD]]'' {{PubMed|25217586}}
  
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yheH_1047072_1049093_1 bmrD] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yheH_1047072_1049093_1 bmrD] {{PubMed|22383849}}
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* '''Regulation:'''  
 
* '''Regulation:'''  
 +
** induced in response to antibiotics that target protein synthesis ([[BmrB]]) {{PubMed|25217586}}
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** ''[[bmrC]]-[[bmrD]]'' expression only occurs during the late-exponential and stationary growth stages, irrespective of the timing of the antibiotic challenge ([[AbrB]]) {{PubMed|25217586}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
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** [[AbrB]]: transcription repression {{PubMed|25217586}}
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** [[BmrB]]: transcriptional attenuation {{PubMed|25217586}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''
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=References=
 
=References=
'''Additional publications:''' {{PubMed|21602923}}
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<pubmed>19167342,10092453,16487324 25217586 21602923</pubmed>
<pubmed>19167342,10092453,16487324</pubmed>
 
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 08:43, 19 September 2014

  • Description: multidrug ABC transporter (ATP-binding protein), also involved in the signalling pathway to activate KinA at the onset of sporulation

Gene name bmrD
Synonyms yheH
Essential no
Product multidrug ABC transporter (ATP-binding protein)
Function multiple antibiotic resistance
Gene expression levels in SubtiExpress: bmrD
Interactions involving this protein in SubtInteract: BmrD
MW, pI 76 kDa, 7.082
Gene length, protein length 2019 bp, 673 aa
Immediate neighbours bmrC, yheG
Sequences Protein DNA DNA_with_flanks
Genetic context
YheH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
BmrD expression.png















Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics, membrane proteins, sporulation proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU09720

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: has both a membrane-spanning and an ATP-binding domain PubMed
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • induced in response to antibiotics that target protein synthesis (BmrB) PubMed
    • bmrC-bmrD expression only occurs during the late-exponential and stationary growth stages, irrespective of the timing of the antibiotic challenge (AbrB) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References