SigE

• Description: RNA polymerase sporulation mother cell-specific (early) sigma factor SigE
  
  

Gene name	sigE
Synonyms	spoIIGB
Essential	no
Product	RNA polymerase sporulation mother cell-specific (early) sigma factor SigE
Function	transcription of sporulation genes (early mother cell)
Gene expression levels in SubtiExpress: sigE
Interactions involving this protein in SubtInteract: SigE
Metabolic function and regulation of this protein in SubtiPathways: sigE
MW, pI	27 kDa, 9.212
Gene length, protein length	717 bp, 239 aa
Immediate neighbours	spoIIGA, sigG
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription, sigma factors and their control

This gene is a member of the following regulons

SinR regulon, Spo0A regulon, Efp-dependent proteins

The gene

Basic information

• Locus tag: BSU15320

Database entries

• BsubCyc: BSU15320

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: RNA polymerase sigma factor, active in the mother cell

• Protein family: sigma-70 factor family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • SigE-(RpoB-RpoC)
  • SpoIIGA-SigE (Processing) PubMed

• Localization:

Database entries

• BsubCyc: BSU15320

• Structure:

• UniProt: P06222

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: spoIIGA-sigE-sigG PubMed

• Expression browser: sigE PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • expressed under conditions that trigger sporulation (Spo0A) PubMed

• Regulatory mechanism:
  • repression by SinR
  • Spo0A: transcription activation PubMed

• Additional information:
  • translation is likely to require Efp due to the presence of several consecutive proline residues PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

• Bill Haldenwang, San Antonio, USA
• Charles Moran, Emory University, NC, USA homepage

References

Reviews

Michiel J L de Hoon, Patrick Eichenberger, Dennis Vitkup
Hierarchical evolution of the bacterial sporulation network.
Curr Biol: 2010, 20(17);R735-45
[PubMed:20833318] [WorldCat.org] [DOI] (I p)

Original Publications

Additional publications: PubMed