Difference between revisions of "YkoV"
| Line 1: | Line 1: | ||
| − | * '''Description:''' confers dry-heat resistance to dormant spores [http://www.ncbi.nlm.nih.gov/sites/entrez/16497325 PubMed] | + | * '''Description:''' DNA-end-binding protein Ku, recruits [[LigD]] to DNA ends, confers dry-heat resistance to dormant spores [http://www.ncbi.nlm.nih.gov/sites/entrez/16497325 PubMed] |
<br/><br/> | <br/><br/> | ||
| Line 11: | Line 11: | ||
|style="background:#ABCDEF;" align="center"| '''Essential''' || no | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"| '''Product''' || | + | |style="background:#ABCDEF;" align="center"| '''Product''' || DNA-end-binding protein Ku |
|- | |- | ||
|style="background:#ABCDEF;" align="center"|'''Function''' || non-homologous end joining DNA repair | |style="background:#ABCDEF;" align="center"|'''Function''' || non-homologous end joining DNA repair | ||
| Line 21: | Line 21: | ||
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 933 bp, 311 aa | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 933 bp, 311 aa | ||
|- | |- | ||
| − | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ | + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ligD]]'', ''[[ykoW]]'' |
|- | |- | ||
|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13410 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13410 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13410 DNA_with_flanks] | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU13410 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU13410 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU13410 DNA_with_flanks] | ||
| Line 106: | Line 106: | ||
=Expression and regulation= | =Expression and regulation= | ||
| − | * '''Operon:''' ''[[ykoV]]-[[ | + | * '''Operon:''' ''[[ykoV]]-[[ligD]]'' {{PubMed|16497325}} |
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ykoV_1406357_1407292_-1 ykoV] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=ykoV_1406357_1407292_-1 ykoV] {{PubMed|22383849}} | ||
Revision as of 11:03, 23 May 2013
- Description: DNA-end-binding protein Ku, recruits LigD to DNA ends, confers dry-heat resistance to dormant spores PubMed
| Gene name | ykoV |
| Synonyms | |
| Essential | no |
| Product | DNA-end-binding protein Ku |
| Function | non-homologous end joining DNA repair |
| Gene expression levels in SubtiExpress: ykoV | |
| MW, pI | 34 kDa, 7.213 |
| Gene length, protein length | 933 bp, 311 aa |
| Immediate neighbours | ligD, ykoW |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
DNA repair/ recombination, sporulation proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU13410
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- associates with the nucleoid during germination PubMed
Database entries
- Structure:
- UniProt: O34859
- KEGG entry: [2]
- E.C. number:
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Stewart Shuman, Michael S Glickman
Bacterial DNA repair by non-homologous end joining.
Nat Rev Microbiol: 2007, 5(11);852-61
[PubMed:17938628]
[WorldCat.org]
[DOI]
(I p)
A J Doherty, S P Jackson
DNA repair: how Ku makes ends meet.
Curr Biol: 2001, 11(22);R920-4
[PubMed:11719239]
[WorldCat.org]
[DOI]
(P p)
J M Jones, M Gellert, W Yang
A Ku bridge over broken DNA.
Structure: 2001, 9(10);881-4
[PubMed:11591342]
[WorldCat.org]
[DOI]
(P p)
Original publications
Miguel de Vega
The minimal Bacillus subtilis nonhomologous end joining repair machinery.
PLoS One: 2013, 8(5);e64232
[PubMed:23691176]
[WorldCat.org]
[DOI]
(I e)
Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325]
[WorldCat.org]
[DOI]
(P p)
Geoffrey R Weller, Boris Kysela, Rajat Roy, Louise M Tonkin, Elizabeth Scanlan, Marina Della, Susanne Krogh Devine, Jonathan P Day, Adam Wilkinson, Fabrizio d'Adda di Fagagna, Kevin M Devine, Richard P Bowater, Penny A Jeggo, Stephen P Jackson, Aidan J Doherty
Identification of a DNA nonhomologous end-joining complex in bacteria.
Science: 2002, 297(5587);1686-9
[PubMed:12215643]
[WorldCat.org]
[DOI]
(I p)
L Aravind, E V Koonin
Prokaryotic homologs of the eukaryotic DNA-end-binding protein Ku, novel domains in the Ku protein and prediction of a prokaryotic double-strand break repair system.
Genome Res: 2001, 11(8);1365-74
[PubMed:11483577]
[WorldCat.org]
[DOI]
(P p)
