Difference between revisions of "ExoA"
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|style="background:#ABCDEF;" align="center"|'''Function''' || repair of oxidative DNA damage in spores | |style="background:#ABCDEF;" align="center"|'''Function''' || repair of oxidative DNA damage in spores | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU40880 exoA] |
|- | |- | ||
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 4.592 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 29 kDa, 4.592 | ||
| Line 22: | Line 22: | ||
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ccpB]]'', ''[[rpsR]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ccpB]]'', ''[[rpsR]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU40880 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU40880 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU40880 Advanced_DNA] |
|- | |- | ||
|colspan="2" | '''Genetic context''' <br/> [[Image:exoA_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:exoA_context.gif]] | ||
Revision as of 14:20, 13 May 2013
- Description: apurinic/apyrimidinic endonuclease, multifunctional DNA-repair enzyme, important for spore dormance
| Gene name | exoA |
| Synonyms | |
| Essential | no |
| Product | apurinic/apyrimidinic endonuclease |
| Function | repair of oxidative DNA damage in spores |
| Gene expression levels in SubtiExpress: exoA | |
| MW, pI | 29 kDa, 4.592 |
| Gene length, protein length | 756 bp, 252 aa |
| Immediate neighbours | ccpB, rpsR |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
DNA repair/ recombination, sporulation proteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU40880
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates (according to Swiss-Prot)
- Protein family: DNA repair enzymes AP/exoA family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P37454
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- available in Mario Pedraza-Reyes' lab
- GP898 (exoA::kan), available in Stülke lab
- GP1503 (exoA::kan, nfo::cat), available in Stülke lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
