Difference between revisions of "RapI"
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=== Database entries === | === Database entries === | ||
| − | * '''Structure:''' | + | * '''Structure:''' [http://www.rcsb.org/pdb/explore/explore.do?structureId=4I1A 4I1A] {{PubMed|23526881}} |
* '''UniProt:''' [http://www.uniprot.org/uniprot/P96649 P96649] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P96649 P96649] | ||
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=References= | =References= | ||
| − | <pubmed> 11466295 17511812 </pubmed> | + | <pubmed> 11466295 17511812 23526881</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 17:40, 27 March 2013
- Description: response regulator aspartate phosphatase, antagonist of ImmR
| Gene name | rapI |
| Synonyms | yddL |
| Essential | no |
| Product | response regulator aspartate phosphatase |
| Function | control of transfer of the mobile genetic element ICEBs1 |
| Gene expression levels in SubtiExpress: rapI | |
| Interactions involving this protein in SubtInteract: RapI | |
| MW, pI | 46 kDa, 5.054 |
| Gene length, protein length | 1173 bp, 391 aa |
| Immediate neighbours | yddK, phrI |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
protein modification, transcription factors and their control, quorum sensing, mobile genetic elements
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU05010
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: binds ImmR and inhibits its activity, this results in induction of the genes for the transfer of the mobile genetic element ICEBs1 PubMed
- Protein family: RAP family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: binding of PhrI indicates that neighbour cells do already contain the genetic element ICEBs1, this results in inactivation of RapI PubMed
Database entries
- UniProt: P96649
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Vijay Parashar, Philip D Jeffrey, Matthew B Neiditch
Conformational change-induced repeat domain expansion regulates Rap phosphatase quorum-sensing signal receptors.
PLoS Biol: 2013, 11(3);e1001512
[PubMed:23526881]
[WorldCat.org]
[DOI]
(I p)
Jennifer M Auchtung, Catherine A Lee, Katherine L Garrison, Alan D Grossman
Identification and characterization of the immunity repressor (ImmR) that controls the mobile genetic element ICEBs1 of Bacillus subtilis.
Mol Microbiol: 2007, 64(6);1515-28
[PubMed:17511812]
[WorldCat.org]
[DOI]
(P p)
R S McQuade, N Comella, A D Grossman
Control of a family of phosphatase regulatory genes (phr) by the alternate sigma factor sigma-H of Bacillus subtilis.
J Bacteriol: 2001, 183(16);4905-9
[PubMed:11466295]
[WorldCat.org]
[DOI]
(P p)
