Difference between revisions of "FlgM"

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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=flgM_3640285_3640551_-1 flgM] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=flgM_3640285_3640551_-1 flgM] {{PubMed|22383849}}
  
* '''Sigma factor:'''  
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* '''[[Sigma factor]]:'''  
 
** ''[[comFA]]'': [[SigA]] {{PubMed|8412657}}
 
** ''[[comFA]]'': [[SigA]] {{PubMed|8412657}}
 
** ''[[yvyF]]'': [[SigD]] {{PubMed|8045879}}
 
** ''[[yvyF]]'': [[SigD]] {{PubMed|8045879}}
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=References=
 
=References=
 
'''Additional publications:''' {{PubMed|21736639}}  
 
'''Additional publications:''' {{PubMed|21736639}}  
<pubmed>8955328,19898538 8412657 8045879 , 20233303 10207036 8655488 </pubmed>
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<pubmed>8955328,19898538 8412657 8045879 , 20233303 10207036 8655488 23352839 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 10:08, 1 February 2013

  • Description: anti-SigD, regulation of flagellin, motility, and chemotaxis

Gene name flgM
Synonyms
Essential no
Product anti-SigD
Function control of SigD activity
Gene expression levels in SubtiExpress: flgM
Interactions involving this protein in SubtInteract: FlgM
MW, pI 9 kDa, 9.918
Gene length, protein length 264 bp, 88 aa
Immediate neighbours yvyG, yvyF
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
FlgM context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FlgM expression.png















Categories containing this gene/protein

sigma factors and their control, motility and chemotaxis

This gene is a member of the following regulons

ComK regulon, DegU regulon, ScoC regulon, SigD regulon

The gene

Basic information

  • Locus tag: BSU35430

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: flgM family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Wai Kit Ma, Rachel Hendrix, Claire Stewart, Eric V Campbell, Mitchell Lavarias, Kolyn Morris, Shauna Nichol, Matthew J Gage
FlgM proteins from different bacteria exhibit different structural characteristics.
Biochim Biophys Acta: 2013, 1834(4);808-16
[PubMed:23352839] [WorldCat.org] [DOI] (P p)

Loralyn M Cozy, Daniel B Kearns
Gene position in a long operon governs motility development in Bacillus subtilis.
Mol Microbiol: 2010, 76(2);273-85
[PubMed:20233303] [WorldCat.org] [DOI] (I p)

Prashant Kodgire, K Krishnamurthy Rao
A dual mode of regulation of flgM by ScoC in Bacillus subtilis.
Can J Microbiol: 2009, 55(8);983-9
[PubMed:19898538] [WorldCat.org] [DOI] (I p)

M G Bertero, B Gonzales, C Tarricone, F Ceciliani, A Galizzi
Overproduction and characterization of the Bacillus subtilis anti-sigma factor FlgM.
J Biol Chem: 1999, 274(17);12103-7
[PubMed:10207036] [WorldCat.org] [DOI] (P p)

K Fredrick, J D Helmann
FlgM is a primary regulator of sigmaD activity, and its absence restores motility to a sinR mutant.
J Bacteriol: 1996, 178(23);7010-3
[PubMed:8955328] [WorldCat.org] [DOI] (P p)

T Caramori, D Barilla, C Nessi, L Sacchi, A Galizzi
Role of FlgM in sigma D-dependent gene expression in Bacillus subtilis.
J Bacteriol: 1996, 178(11);3113-8
[PubMed:8655488] [WorldCat.org] [DOI] (P p)

D B Mirel, P Lauer, M J Chamberlin
Identification of flagellar synthesis regulatory and structural genes in a sigma D-dependent operon of Bacillus subtilis.
J Bacteriol: 1994, 176(15);4492-500
[PubMed:8045879] [WorldCat.org] [DOI] (P p)

J A Londoño-Vallejo, D Dubnau
comF, a Bacillus subtilis late competence locus, encodes a protein similar to ATP-dependent RNA/DNA helicases.
Mol Microbiol: 1993, 9(1);119-31
[PubMed:8412657] [WorldCat.org] [DOI] (P p)