Difference between revisions of "BdbB"
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| − | + | * '''Description:''' thiol-disulfide oxidoreductase <br/><br/> | |
| + | |||
| + | {| align="right" border="1" cellpadding="2" | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"|'''Gene name''' | ||
| + | |''bdbB'' | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''yolK '' | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Product''' || thiol-disulfide oxidoreductase | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"|'''Function''' || trans-acting protein folding catalyst, protein secretion | ||
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/wiki/index.php/Protein_secretion Protein secretion]''' | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 16 kDa, 9.415 | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 444 bp, 148 aa | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[bhlB]]'', ''[[sunS]]'' | ||
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14062]+-newId sequences] <br/> (Barbe ''et al.'', 2009)''' | ||
| + | |- | ||
| + | |colspan="2" | '''Genetic context''' <br/> [[Image:bdbB_context.gif]] | ||
| + | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
| + | |- | ||
| + | |} | ||
| + | |||
| + | __TOC__ | ||
| + | |||
| + | <br/><br/> | ||
| + | |||
| + | = [[Categories]] containing this gene/protein = | ||
| + | {{SubtiWiki category|[[chaperones/ protein folding]]}}, | ||
| + | {{SubtiWiki category|[[SP-beta prophage]]}}, | ||
| + | {{SubtiWiki category|[[membrane proteins]]}} | ||
| + | |||
| + | = This gene is a member of the following [[regulons]] = | ||
| + | {{SubtiWiki regulon|[[Abh regulon]]}}, | ||
| + | {{SubtiWiki regulon|[[AbrB regulon]]}}, | ||
| + | {{SubtiWiki regulon|[[Rok regulon]]}}, | ||
| + | {{SubtiWiki regulon|[[YvrHb regulon]]}} | ||
| + | |||
| + | =The gene= | ||
| + | |||
| + | === Basic information === | ||
| + | |||
| + | * '''Locus tag:''' BSU21440 | ||
| + | |||
| + | ===Phenotypes of a mutant === | ||
| + | |||
| + | === Database entries === | ||
| + | |||
| + | * '''DBTBS entry:''' [http://dbtbs.hgc.jp/COG/prom/sunT-bdbA-yolJ-bdbB.html] | ||
| + | |||
| + | * '''SubtiList entry:''' [http://genolist.pasteur.fr/SubtiList/genome.cgi?gene_detail+BG13587] | ||
| + | |||
| + | === Additional information=== | ||
| + | |||
| + | |||
| + | |||
| + | |||
| + | =The protein= | ||
| + | |||
| + | === Basic information/ Evolution === | ||
| + | |||
| + | * '''Catalyzed reaction/ biological activity:''' | ||
| + | |||
| + | * '''Protein family:''' NAD-dependent glycerol-3-phosphate dehydrogenase family (according to Swiss-Prot) | ||
| + | |||
| + | * '''Paralogous protein(s):''' | ||
| + | |||
| + | === Extended information on the protein === | ||
| + | |||
| + | * '''Kinetic information:''' | ||
| + | |||
| + | * '''Domains:''' | ||
| + | |||
| + | * '''Modification:''' | ||
| + | |||
| + | * '''Cofactor(s):''' | ||
| + | |||
| + | * '''Effectors of protein activity:''' | ||
| + | |||
| + | * '''[[SubtInteract|Interactions]]:''' | ||
| + | |||
| + | * '''[[Localization]]:''' cell membrane (according to Swiss-Prot) | ||
| + | |||
| + | === Database entries === | ||
| + | |||
| + | * '''Structure:''' | ||
| + | |||
| + | * '''UniProt:''' [http://www.uniprot.org/uniprot/P68571 P68571] | ||
| + | |||
| + | * '''KEGG entry:''' [http://www.genome.jp/dbget-bin/www_bget?bsu:BSU21440] | ||
| + | |||
| + | * '''E.C. number:''' | ||
| + | |||
| + | === Additional information=== | ||
| + | |||
| + | =Expression and regulation= | ||
| + | |||
| + | ** '''Operon:''' ''[[sunT]]-[[bdbA]]-[[sunS]]-[[bdbB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed] | ||
| + | |||
| + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=bdbB_2265225_2265671_-1 bdbB] {{PubMed|22383849}} | ||
| + | |||
| + | * '''Sigma factor:''' | ||
| + | |||
| + | * '''Regulation:''' | ||
| + | ** repressed by [[Rok]] [http://www.ncbi.nlm.nih.gov/sites/entrez/15743949 PubMed] | ||
| + | |||
| + | * '''Regulatory mechanism:''' | ||
| + | ** activated by [[YvrHb]] [http://www.ncbi.nlm.nih.gov/sites/entrez/16306698 PubMed] | ||
| + | ** [[Rok]]: transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/15743949 PubMed] | ||
| + | ** [[AbrB]]: transcription repression{{PubMed|20817675}} | ||
| + | ** [[Abh]]: transcription activation {{PubMed|20817675}} | ||
| + | |||
| + | * '''Additional information:''' | ||
| + | |||
| + | =Biological materials = | ||
| + | |||
| + | * '''Mutant:''' | ||
| + | |||
| + | * '''Expression vector:''' | ||
| + | |||
| + | * '''lacZ fusion:''' | ||
| + | |||
| + | * '''GFP fusion:''' | ||
| + | |||
| + | * '''two-hybrid system:''' | ||
| + | |||
| + | * '''Antibody:''' | ||
| + | |||
| + | =Labs working on this gene/protein= | ||
| + | |||
| + | =Your additional remarks= | ||
| + | |||
| + | =References= | ||
| + | '''Additional publications:''' {{PubMed|20817675}} | ||
| + | <pubmed>11872755 15743949, </pubmed> | ||
| + | |||
| + | [[Category:Protein-coding genes]] | ||
Revision as of 18:53, 18 April 2012
- Description: thiol-disulfide oxidoreductase
| Gene name | bdbB |
| Synonyms | yolK |
| Essential | no |
| Product | thiol-disulfide oxidoreductase |
| Function | trans-acting protein folding catalyst, protein secretion |
| Metabolic function and regulation of this protein in SubtiPathways: Protein secretion | |
| MW, pI | 16 kDa, 9.415 |
| Gene length, protein length | 444 bp, 148 aa |
| Immediate neighbours | bhlB, sunS |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
chaperones/ protein folding, SP-beta prophage, membrane proteins
This gene is a member of the following regulons
Abh regulon, AbrB regulon, Rok regulon, YvrHb regulon
The gene
Basic information
- Locus tag: BSU21440
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: NAD-dependent glycerol-3-phosphate dehydrogenase family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P68571
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Sigma factor:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Additional publications: PubMed
Mark Albano, Wiep Klaas Smits, Linh T Y Ho, Barbara Kraigher, Ines Mandic-Mulec, Oscar P Kuipers, David Dubnau
The Rok protein of Bacillus subtilis represses genes for cell surface and extracellular functions.
J Bacteriol: 2005, 187(6);2010-9
[PubMed:15743949]
[WorldCat.org]
[DOI]
(P p)
Ronald Dorenbos, Torsten Stein, Jorrit Kabel, Claude Bruand, Albert Bolhuis, Sierd Bron, Wim J Quax, Jan Maarten Van Dijl
Thiol-disulfide oxidoreductases are essential for the production of the lantibiotic sublancin 168.
J Biol Chem: 2002, 277(19);16682-8
[PubMed:11872755]
[WorldCat.org]
[DOI]
(P p)
