SasA

• Description: (p)ppGpp synthetase, small alarmone synthetase
  
  

Gene name	ywaC
Synonyms	ipa-7d
Essential	no
Product	(p)ppGpp synthetase
Function	ppGpp synthesis independent from stringent response
MW, pI	24 kDa, 6.217
Gene length, protein length	630 bp, 210 aa
Immediate neighbours	ywaD, menA
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

metabolism of signalling nucleotides, cell envelope stress proteins (controlled by SigM, V, W, X, Y)

This gene is a member of the following regulons

SigM regulon SigW regulon

The gene

Basic information

• Locus tag: BSU38480

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s): YjbM

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P39583

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ywaC PubMed

• Expression browser: ywaC PubMed

• Sigma factor: SigM PubMed SigW PubMed

• Regulation:
  • transcription is highly upregulated in response to lesions in late-acting teichoic acid synthesis genes tagB, tagD and tagF, and also in response to cell-wall-active compounds like bacitracin or vancomycin PubMed
  • expression is reduced in a SigV mutant PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed