PpsC

• Description: plipastatin synthetase
  
  

Gene name	ppsC
Synonyms
Essential	no
Product	plipastatin synthetase
Function	production of the antibacterial compound plipastatin
MW, pI	287 kDa, 5.352
Gene length, protein length	7665 bp, 2555 aa
Immediate neighbours	ppsD, ppsB
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

miscellaneous metabolic pathways, biosynthesis of antibacterial compounds

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU18320

Expression

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: ATP-dependent AMP-binding enzyme family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • PpsC is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of interactions PubMed

• Localization:

Database entries

• Structure:

• UniProt: P39847

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: ppsA-ppsB-ppsC-ppsD-ppsE PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed

Elodie Marchadier, Rut Carballido-López, Sophie Brinster, Céline Fabret, Peggy Mervelet, Philippe Bessières, Marie-Françoise Noirot-Gros, Vincent Fromion, Philippe Noirot
An expanded protein-protein interaction network in Bacillus subtilis reveals a group of hubs: Exploration by an integrative approach.
Proteomics: 2011, 11(15);2981-91
[PubMed:21630458] [WorldCat.org] [DOI] (I p)

K Tsuge, T Ano, M Hirai, Y Nakamura, M Shoda
The genes degQ, pps, and lpa-8 (sfp) are responsible for conversion of Bacillus subtilis 168 to plipastatin production.
Antimicrob Agents Chemother: 1999, 43(9);2183-92
[PubMed:10471562] [WorldCat.org] [DOI] (P p)

Valentina Tosato, Alessandra M Albertini, Michela Zotti, Sabrina Sonda, Carlo V Bruschi
Sequence completion, identification and definition of the fengycin operon in Bacillus subtilis 168.
Microbiology (Reading): 1997, 143 ( Pt 11);3443-3450
[PubMed:9387222] [WorldCat.org] [DOI] (P p)