TcyN

• Description: cystine ABC transporter (ATP-binding protein)
  
  

Gene name	tcyN
Synonyms	hisP, ytmN
Essential	no
Product	cystine ABC transporter (ATP-binding protein)
Function	cystine uptake
Interactions involving this protein in SubtInteract: TcyN
Metabolic function and regulation of this protein in SubtiPathways: Riboflavin / FAD
MW, pI	29 kDa, 8.835
Gene length, protein length	777 bp, 259 aa
Immediate neighbours	ytmO, tcyM
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

ABC transporters, biosynthesis/ acquisition of amino acids, membrane proteins

This gene is a member of the following regulons

CymR regulon, YtlI regulon

The gene

Basic information

• Locus tag: BSU29340

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions: TcyN-(TcyL-TcyM)-(TcyJ-TcyK) PubMed

• Localization: attached to the membrane via TcyL-TcyM PubMed

Database entries

• Structure: 2Q0H (complex with ADP-Mg2+, Geobacillus stearothermophilus, 54% identity )

• UniProt: O34900

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: ytmI-tcyJ-tcyK-tcyL-tcyM-tcyN-ytmO-ytnI-ytnJ-ribR-ytnL-ytnM PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed in the presence of cysteine (CymR) PubMed

• Regulatory mechanism:
  • CymR: transcription repression PubMed
  • YtlI: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed