GntZ

• Description: 6-phosphogluconate dehydrogenase
  
  

Gene name	gntZ
Synonyms
Essential	no
Product	6-phosphogluconate dehydrogenase
Function	gluconate utilization
Metabolic function and regulation of this protein in SubtiPathways: Sugar catabolism
MW, pI	51 kDa, 4.756
Gene length, protein length	1404 bp, 468 aa
Immediate neighbours	gntP, ahpC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

Categories containing this gene/protein

utilization of specific carbon sources

This gene is a member of the following regulons

AbrB regulon, CcpA regulon, GntR regulon

The gene

Basic information

• Locus tag: BSU40080

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: 6-phospho-D-gluconate + NADP⁺ = D-ribulose 5-phosphate + CO₂ + NADPH (according to Swiss-Prot)

• Protein family: 6-phosphogluconate dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P12013

• KEGG entry: [3]

• E.C. number: 1.1.1.44

Expression and regulation

• Operon:
  • gntR-gntK-gntP-gntZ PubMed1 PubMed2
  • gntZ PubMed

• Sigma factor:
  • gntR: SigA PubMed
  • gntZ: SigA PubMed

• Regulation:
  • induced by gluconate (GntR) PubMed
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • GntR: transcription repression PubMed
  • CcpA: transcription repression PubMed
  • AbrB: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Additional publications: PubMed