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| − | [[Image: | + | Biofilms are the result of the multicellular lifestyle of ''B. subtilis''. They are characterized by the formation of a matrix polysaccharide and an amyloid-like protein, [[TasA]]. |
| + | |||
| + | {| align="right" border="1" cellpadding="2" | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"|'''Gene name''' | ||
| + | |''sinR'' | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Synonyms''' || ''sin, flaD '' | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Essential''' || no | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Product''' || transcriptional regulator of post-exponential-phase responses genes | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"|'''Function''' || control of [[biofilm formation]] | ||
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm], [http://subtiwiki.uni-goettingen.de/pathways/carbon_flow.html Central C-metabolism]''' | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 12 kDa, 7.177 | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 333 bp, 111 aa | ||
| + | |- | ||
| + | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[sinI]]'', ''[[tasA]]'' | ||
| + | |- | ||
| + | |colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+[EMBLCDS:CAB14392]+-newId sequences] <br/> (Barbe ''et al.'', 2009)''' | ||
| + | |- | ||
| + | |colspan="2" | '''Genetic context''' <br/> [[Image:sinR_context.gif]] | ||
| + | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
| + | |- | ||
| + | |} | ||
| + | |||
| + | __TOC__ | ||
| + | |||
| + | ==[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm formation in ''Subti''Pathways]== | ||
| + | |||
| + | ==Labs working on biofilm formation== | ||
| + | * [[Daniel Kearns]] | ||
| + | * [[Oscar Kuipers]] | ||
| + | * [[Beth Lazazzera]] | ||
| + | * [[Richard Losick]] | ||
| + | * [[Nicola Stanley-Wall]] | ||
| + | |||
| + | ==Key genes and operons involved in biofilm formation== | ||
| + | * matrix polysaccharide synthesis: | ||
| + | ** ''[[epsA]]-[[epsB]]-[[epsC]]-[[epsD]]-[[epsE]]-[[epsF]]-[[epsG]]-[[epsH]]-[[epsI]]-[[epsJ]]-[[epsK]]-[[epsL]]-[[epsM]]-[[epsN]]-[[epsO]]'' | ||
| + | * amyloid protein synthesis | ||
| + | ** ''[[yqxM]]-[[sipW]]-[[tasA]]'' | ||
| + | * regulation | ||
| + | ** [[SlrR]] | ||
| + | ** [[SlrA]] | ||
| + | ** [[SinR]] | ||
| + | ** [[SinI]] | ||
| + | ** [[PtkA]] | ||
| + | ** [[TkmA]] | ||
| + | ** [[PtpZ]] | ||
| + | ** [[DegU]] | ||
| + | ** [[RacX]] | ||
| + | * biofilm disassembly | ||
| + | ** [[YlmE]] | ||
| + | * other proteins required for biofilm formation | ||
| + | ** [[SpeA]] | ||
| + | ** [[YmcA]] | ||
| + | ** [[YxaB]] | ||
| + | |||
| + | ==Key reviews== | ||
| + | <pubmed>19054118 19054118 16787201 9891794 20890834 </pubmed> | ||
| + | * additional reviews: {{PubMed|20735481}} | ||
Revision as of 13:21, 9 November 2010
Biofilms are the result of the multicellular lifestyle of B. subtilis. They are characterized by the formation of a matrix polysaccharide and an amyloid-like protein, TasA.
| Gene name | sinR |
| Synonyms | sin, flaD |
| Essential | no |
| Product | transcriptional regulator of post-exponential-phase responses genes |
| Function | control of biofilm formation |
| Metabolic function and regulation of this protein in SubtiPathways: Biofilm, Central C-metabolism | |
| MW, pI | 12 kDa, 7.177 |
| Gene length, protein length | 333 bp, 111 aa |
| Immediate neighbours | sinI, tasA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Biofilm formation in SubtiPathways
Labs working on biofilm formation
Key genes and operons involved in biofilm formation
- matrix polysaccharide synthesis:
- amyloid protein synthesis
- regulation
- biofilm disassembly
- other proteins required for biofilm formation
Key reviews
Roberto Kolter
Biofilms in lab and nature: a molecular geneticist's voyage to microbial ecology.
Int Microbiol: 2010, 13(1);1-7
[PubMed:20890834]
[WorldCat.org]
[DOI]
(I p)
Daniel Lopez, Hera Vlamakis, Roberto Kolter
Generation of multiple cell types in Bacillus subtilis.
FEMS Microbiol Rev: 2009, 33(1);152-63
[PubMed:19054118]
[WorldCat.org]
[DOI]
(P p)
Wolf-Rainer Abraham
Controlling biofilms of gram-positive pathogenic bacteria.
Curr Med Chem: 2006, 13(13);1509-24
[PubMed:16787201]
[WorldCat.org]
[DOI]
(P p)
J A Shapiro
Thinking about bacterial populations as multicellular organisms.
Annu Rev Microbiol: 1998, 52;81-104
[PubMed:9891794]
[WorldCat.org]
[DOI]
(P p)
- additional reviews: PubMed
