Difference between revisions of "CtsR"
| Line 66: | Line 66: | ||
* '''Domains:''' | * '''Domains:''' | ||
| − | * '''Modification:''' phosphorylation of a tyrosine residue by [[McsB]] [http://www.ncbi.nlm.nih.gov/sites/entrez/14984053 PubMed] | + | * '''Modification:''' |
| + | ** phosphorylation of a tyrosine residue by [[McsB]] [http://www.ncbi.nlm.nih.gov/sites/entrez/14984053 PubMed] | ||
| + | ** recently, it was reported that CtsR is phosphorylated by [[McsB]] on Arg-62 rather than on a tyrosine residue [http://www.ncbi.nlm.nih.gov/sites/entrez/19498169 PubMed] | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
| − | * '''Effectors of protein activity:''' | + | * '''Effectors of protein activity:''' |
| + | ** CtsR is inactivated by heat, heat sensing requires Gly-64 {{PubMed|20852588}} | ||
| + | ** non-phosphorylated [[McsB]] targets CtsR for degradation {{PubMed|20852588}} | ||
| + | ** regulated proteolysis by [[ClpP]]/[[ClpC]] {{PubMed|11179229,16163393,17380125}} | ||
| − | * '''Interactions:''' [[McsA]]-[[McsB]]-[[CtsR]] | + | * '''Interactions:''' [[McsA]]-[[McsB]]-[[CtsR]] |
| + | ** [[CtsR]]-[[ClpP]]/[[ClpC]] (degradation of [[CtsR]]) {{PubMed|11179229,16163393,17380125}} | ||
* '''Localization:''' | * '''Localization:''' | ||
Revision as of 08:56, 26 October 2010
| Gene name | ctsR |
| Synonyms | yacG |
| Essential | no |
| Product | transcription repressor |
| Function | regulation of protein degradation |
| Regulatory function and regulation of this protein in SubtiPathways: Stress, Phosphorelay | |
| MW, pI | 17 kDa, 9.261 |
| Gene length, protein length | 462 bp, 154 aa |
| Immediate neighbours | rrnW-5S, mcsA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU00830
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: ctsR family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- UniProt: P37568
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Additional information: the mRNA is very stable (half-life > 15 min) PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Wolfgang Schumann
The Bacillus subtilis heat shock stimulon.
Cell Stress Chaperones: 2003, 8(3);207-17
[PubMed:14984053]
[WorldCat.org]
[DOI]
(P p)
Original publications
Additional publications: PubMed
