Response regulator aspartate phosphatases

These proteins contain the so-called tetratricopeptide repeats (TPRs) protein-protein interaction module. They control the phosphorelay for sporulation initiation by dephosphorylating Spo0F-P or they inhibit transcription factors by protein-protein interaction (without affecting phosphorylation). The activity of these proteins can be controlled by small peptides that are expressed as precursors, exported, and re-imported into the cell.

The RAP proteins of B. subtilis, their cognate peptides and target proteins

• RapA, PhrA: RapA dephosphorylates Spo0F-P
• RapB: dephosphorylates Spo0F-P
• RapC, PhrC: RapC inhibits the DNA-binding activity of ComA-P
• RapD: RapD inhibits the DNA-binding activity of ComA-P
• RapE, PhrE: RapE dephosphorylates Spo0F-P
• RapF, PhrF: RapF inhibits the DNA-binding activity of ComA-P
• RapG, PhrG: RapG inhibits the DNA-binding activity of DegU-P
• RapH: bifuntional protein: dephosphorylates Spo0F-P and inhibits the DNA-binding activity of ComA-P
• RapI, PhrI: RapI inhibits the DNA-binding activity of ImmR
• RapJ: unknown function
• RapK, PhrK: RapK inhibits the DNA-binding activity of ComA-P

Related lists

• two-component systems
• phosphorelay