Difference between revisions of "ManP"

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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU12010&redirect=T BSU12010]
  
 
* '''DBTBS entry:''' no entry
 
* '''DBTBS entry:''' no entry
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=== Database entries ===
 
=== Database entries ===
 +
* '''BsubCyc:''' [http://bsubcyc.org/BSUB/NEW-IMAGE?type=NIL&object=BSU12010&redirect=T BSU12010]
  
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2R48 2R48] (IIB domain)
 
* '''Structure:''' [http://www.rcsb.org/pdb/explore.do?structureId=2R48 2R48] (IIB domain)

Revision as of 13:27, 2 April 2014

Gene name manP
Synonyms yjdD
Essential no
Product trigger enzyme: mannose-specific phosphotransferase system, EIIBCA
Function mannose uptake and phosphorylation, control of ManR activity
Gene expression levels in SubtiExpress: manP
Interactions involving this protein in SubtInteract: ManP
Metabolic function and regulation of this protein in SubtiPathways:
manP
MW, pI 61 kDa, 6.715
Gene length, protein length 1767 bp, 589 aa
Immediate neighbours manR, manA
Sequences Protein DNA DNA_with_flanks
Genetic context
ManP context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ManP expression.png



















Categories containing this gene/protein

phosphotransferase systems, utilization of specific carbon sources, transcription factors and their control, trigger enzyme, membrane proteins, phosphoproteins

This gene is a member of the following regulons

ManR regulon

The gene

Basic information

  • Locus tag: BSU12010

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transport and concomitant phosphorylation of mannose
  • Protein family: PTS permease, fructose/ mannitol permease (Fru) family PubMed
  • Paralogous protein(s): FruA

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification: phosphorylation on Ser-365 PubMed
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2R48 (IIB domain)
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • induced by mannose (ManR) PubMed
    • repressed by glucose (ManR) PubMed
    • strongly induced in response to glucose starvation in M9 medium PubMed
  • Regulatory mechanism:
    • ManR: transcription activation in the presence of mannose and absence of glucose PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References