fruA
168

fructose-specific permease of the phosphotransferase system, EIIABC of the PTS

Locus

BSU_14400

Molecular weight

67.01 kDa

Isoelectric point

5.24

Protein length

635 aaSequenceBlast

Gene length

1908 bpSequenceBlast

Function

fructose uptake and phosphorylation

Product

fructose-specific PTS, EIIABC

Essential

E.C.

2.7.1.69

Synonyms

fruA

Outlinks

BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Hide small RNAsZoom:

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1762 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene

Coordinates

1,509,256 1,511,163

The protein

Catalyzed reaction/ biological activity

D-fructose + N^π-phospho-L-histidyl-[protein] --> D-fructose 1-phosphate + L-histidyl-[protein] (according to UniProt)

Protein family

PTS permease, fructose/ mannitol family PubMed

Domains

PTS EIIA domain type-2 (aa 5-149) (according to UniProt)

PTS EIIB domain type-2 (aa 172-267) (according to UniProt)

PTS EIIC domain type-2 (aa 301-635) (according to UniProt)

Structure

2R4Q (PDB) (EIIB domain)

P71012 (AlphaFold)

Paralogous protein(s)

ManP

Localization

cell membrane (homogeneous) PubMed

Expression and Regulation

Operons

Genes

fruR-fruK-fruA

Description

PubMed

Regulation

induced in the presence of fructose (FruR) (according to DBTBS)

Regulatory mechanism

FruR: repression, (according to DBTBS), in fruR regulon

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Biological materials

Mutant

BKE14400 (fruA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TATTTTCACTTGTGTTTCCT, downstream forward: _UP4_TAAGAAAAAAAGCGTCCTTG

BKK14400 (fruA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TATTTTCACTTGTGTTTCCT, downstream forward: _UP4_TAAGAAAAAAAGCGTCCTTG

References

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Time of last update: 2025-03-28 00:16:16

Author of last update: Melvin.boenninger

fruA 168

fruA
168