FruA

• Description: fructose-specific phosphotransferase system, EIIABC of the PTS
  
  

Gene name	fruA
Synonyms
Essential	no
Product	fructose-specific phosphotransferase system, EIIABC
Function	fructose uptake and phosphorylation
Gene expression levels in SubtiExpress: fruA
Interactions involving this protein in SubtInteract: FruA
Metabolic function and regulation of this protein in SubtiPathways: fruA
MW, pI	67 kDa, 5.241
Gene length, protein length	1905 bp, 635 aa
Immediate neighbours	fruK, sipT
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

phosphotransferase systems, utilization of specific carbon sources, membrane proteins, phosphoproteins

This gene is a member of the following regulons

FruR regulon

The gene

Basic information

• Locus tag: BSU14400

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine (according to Swiss-Prot)

• Protein family: PTS permease, fructose/ mannitol permease (Fru) family PubMed

• Paralogous protein(s): ManP

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • FruA-HPr
  • FruA is a member of a suspected group of hubs proteins that were suggested to be involved in a large number of interactions PubMed

• Localization: cell membrane (homogeneous) PubMed

Database entries

• Structure: 2R4Q

• UniProt: P71012

• KEGG entry: [3]

• E.C. number: 2.7.1.69

Expression and regulation

• Operon: fruR-fruK-fruA (according to DBTBS)

• Expression browser: fruA PubMed

• Sigma factor:

• Regulation:
  • induced in the presence of fructose (FruR) (according to DBTBS)

• Regulatory mechanism:
  • FruR: transcription repression (according to DBTBS)

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: