TepA

• Description: orphan ClpP-like germination protease, contributes to SASP degradation
  
  

Gene name	tepA
Synonyms	ymfB, ylxI
Essential	no
Product	germination protease
Function	degradation of SASPs
Gene expression levels in SubtiExpress: tepA
Metabolic function and regulation of this protein in SubtiPathways: Protein secretion
MW, pI	24 kDa, 5.575
Gene length, protein length	669 bp, 223 aa
Immediate neighbours	rnjB, ylzJ
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

proteolysis, germination

This gene is a member of the following regulons

SigG regulon, SpoVT regulon,

The gene

Basic information

• Locus tag: BSU16790

Database entries

• BsubCyc: BSU16790

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • degradation of SASPs in germinating spores PubMed

• Protein family: TepA subfamily (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:
  • activity requires YlzJ PubMed

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU16790

• Structure:

• UniProt: Q99171

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: tepA-ylzJ PubMed

• Expression browser: tepA PubMed

• Sigma factor: SigG PubMed

• Regulation:
  • expressed late during sporulation in the forespore (SigG, SpoVT) PubMed

• Regulatory mechanism:
  • SpoVT: transcription repression PubMed

• Additional information:

Biological materials

• Mutant: GP1120 (spc), available in the Stülke lab

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: