Difference between revisions of "LonA"

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|style="background:#ABCDEF;" align="center"|'''Function''' || protein quality control  
 
|style="background:#ABCDEF;" align="center"|'''Function''' || protein quality control  
 
|-
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://cellpublisher.gobics.de/subtiexpress/ ''Subti''Express]''': [http://cellpublisher.gobics.de/subtiexpress/bsu/BSU28200 lonA]
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28200 lonA]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress]'''
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ysxC]]'', ''[[lonB]]''
 
|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[ysxC]]'', ''[[lonB]]''
 
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|colspan="2" style="background:#FAF8CC;" align="center"|'''Get the DNA and protein [http://srs.ebi.ac.uk/srsbin/cgi-bin/wgetz?-e+&#91;EMBLCDS:CAB14780&#93;+-newId sequences] <br/> (Barbe ''et al.'', 2009)'''
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|style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU28200 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU28200 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU28200 Advanced_DNA]
 
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|colspan="2" | '''Genetic context''' <br/> [[Image:lonA_context.gif]]
 
|colspan="2" | '''Genetic context''' <br/> [[Image:lonA_context.gif]]

Revision as of 13:30, 13 May 2013

  • Description: class III heat-shock ATP-dependent protease

Gene name lonA
Synonyms lon
Essential no
Product class III heat-shock ATP-dependent protease
Function protein quality control
Gene expression levels in SubtiExpress: lonA
Regulation of this protein in SubtiPathways:
Stress
MW, pI 86 kDa, 5.774
Gene length, protein length 2322 bp, 774 aa
Immediate neighbours ysxC, lonB
Sequences Protein DNA Advanced_DNA
Genetic context
LonA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
LonA expression.png















Categories containing this gene/protein

proteolysis

This gene is a member of the following regulons

CtsR regulon

The gene

Basic information

  • Locus tag: BSU28200

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

A mutation in lonA suppresses the motility defect of a lytC mutant PubMed

Evidence for a specific DNA binding activitity of the α-domain was found PubMed


The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Hydrolysis of proteins in presence of ATP (according to Swiss-Prot)
  • Protein family: peptidase S16 family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization: coincident with the nucleoid during normal growth and localized to the forespore during development PubMed

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Additional reviews: PubMed

Original publications