RpoC

• Description: RNA polymerase beta' subunit
  
  

Gene name	rpoC
Synonyms
Essential	yes PubMed
Product	RNA polymerase beta' subunit
Function	transcription
Gene expression levels in SubtiExpress: rpoC
Interactions involving this protein in SubtInteract: RpoC
MW, pI	133 kDa, 8.863
Gene length, protein length	3597 bp, 1199 aa
Immediate neighbours	rpoB, ybxF
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

transcription, essential genes, membrane proteins, phosphoproteins

This gene is a member of the following regulons

stringent response

The gene

Basic information

• Locus tag: BSU01080

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1) (according to Swiss-Prot)

• Protein family: RNA polymerase beta' chain family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:
  • phosphorylated on Arg-335 and Arg-803 PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • RpoA-RpoB-RpoC PubMed
  • SigA-(RpoB-RpoC) PubMed, SigB-(RpoB-RpoC)
  • SigD-(RpoB-RpoC), SigE-(RpoB-RpoC)
  • SigF-(RpoB-RpoC), SigG-(RpoB-RpoC)
  • SigH-(RpoB-RpoC), SigI-(RpoB-RpoC)
  • SigK-(RpoB-RpoC), SigL-(RpoB-RpoC)
  • SigM-(RpoB-RpoC), SigV-(RpoB-RpoC)
  • SigW-(RpoB-RpoC), SigX-(RpoB-RpoC)
  • SigY-(RpoB-RpoC), SigZ-(RpoB-RpoC)
  • Xpf-(RpoB-RpoC), YlaC-(RpoB-RpoC)
  • YvrHa-RpoC PubMed

• Localization: membrane associated PubMed

Database entries

• Structure:

• UniProt: P37871

• KEGG entry: [2]

• E.C. number: 2.7.7.6

Expression and regulation

• Operon:

• Expression browser: rpoC PubMed

• Sigma factor:

• Regulation:
  • RelA dependent downregulation (Class I) during stringent response PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Reviews

Lakshminarayan M Iyer, L Aravind
Insights from the architecture of the bacterial transcription apparatus.
J Struct Biol: 2012, 179(3);299-319
[PubMed:22210308] [WorldCat.org] [DOI] (I p)

Original publications

Additional publications: PubMed