Sandbox

• Description: transcriptional activator of the acoA-acoB-acoC-acoL operon
  
  

Gene name	acoR
Synonyms	yfjG, yzcB
Essential	no
Product	transcriptional activator (for SigL-dependent promoter)
Function	regulation of acetoin utilization
Gene expression levels in SubtiExpress: acoR
Interactions involving this protein in SubtInteract: AcoR
Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism
MW, pI	66 kDa, 7.884
Gene length, protein length	1815 bp, 605 aa
Immediate neighbours	acoL, sspH
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of specific carbon sources, transcription factors and their control

This gene is a member of the following regulons

CcpA regulon

The AcoR regulon:

• acoA-acoB-acoC-acoL

The gene

Basic information

• Locus tag: BSU08100

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O31551

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: acoR-sspH PubMed

• Expression browser: acoR PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (3.7-fold) (CcpA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • 1A912 ( acoR::kan), PubMed, available at BGSC
  • 1A912 ( acoR::kan), PubMed, available at BGSC

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Michel Debarbouille, Pasteur Institute, Paris, France Homepage