Difference between revisions of "YcbD"
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| − | + | * '''Description:''' NADP(+)-dependent alpha-ketoglutaric semialdehyde dehydrogenase <br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || utilization of D-glucarate/galactarate | |style="background:#ABCDEF;" align="center"|'''Function''' || utilization of D-glucarate/galactarate | ||
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 52 kDa, 4.787 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 52 kDa, 4.787 | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:ycbD_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ycbD_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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__TOC__ | __TOC__ | ||
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* '''Operon''' ''[[ycbC]]-[[ycbD]]-[[ycbE]]-[[ycbF]]-[[ycbG]]-[[ycbH]]-[[ycbJ]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12044674 PubMed] | * '''Operon''' ''[[ycbC]]-[[ycbD]]-[[ycbE]]-[[ycbF]]-[[ycbG]]-[[ycbH]]-[[ycbJ]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/12044674 PubMed] | ||
| − | * | + | * '''[[Sigma factor]]:''' |
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* '''Regulation:''' induced by D-glucarate/galactarate ([[YcbG]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12044674 PubMed] | * '''Regulation:''' induced by D-glucarate/galactarate ([[YcbG]]) [http://www.ncbi.nlm.nih.gov/sites/entrez/12044674 PubMed] | ||
Revision as of 10:37, 7 August 2012
- Description: NADP(+)-dependent alpha-ketoglutaric semialdehyde dehydrogenase
| Gene name | ycbD |
| Synonyms | |
| Essential | no |
| Product | NADP(+)-dependent alpha-ketoglutaric semialdehyde dehydrogenase |
| Function | utilization of D-glucarate/galactarate |
| MW, pI | 52 kDa, 4.787 |
| Gene length, protein length | 1464 bp, 488 aa |
| Immediate neighbours | ycbC, ycbE |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
utilization of specific carbon sources
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU02470
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: an aldehyde + NAD+ + H2O = an acid + NADH (according to Swiss-Prot)
- Protein family: aldehyde dehydrogenase family (according to Swiss-Prot)
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure: 3RHH (from from Bacillus halodurans C-125 complexed with NADP, 36% identity, 69% similarity)
- UniProt: P42236
- KEGG entry: [3]
- E.C. number: 1.2.1.3
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Seiya Watanabe, Masaki Yamada, Iwao Ohtsu, Keisuke Makino
alpha-ketoglutaric semialdehyde dehydrogenase isozymes involved in metabolic pathways of D-glucarate, D-galactarate, and hydroxy-L-proline. Molecular and metabolic convergent evolution.
J Biol Chem: 2007, 282(9);6685-95
[PubMed:17202142]
[WorldCat.org]
[DOI]
(P p)
Shigeo Hosoya, Kunio Yamane, Michio Takeuchi, Tsutomu Sato
Identification and characterization of the Bacillus subtilis D-glucarate/galactarate utilization operon ycbCDEFGHJ.
FEMS Microbiol Lett: 2002, 210(2);193-9
[PubMed:12044674]
[WorldCat.org]
[DOI]
(P p)
