ycbD

ycbD
168

NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase

Locus
BSU_02470
Molecular weight
52.25 kDa
Isoelectric point
4.79
Protein length
488 aaSequenceBlast
Gene length
1467 bpSequenceBlast
Function
utilization of D-glucarate/galactarate
Product
NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase
Essential
no
E.C.
1.2.1.3
Synonyms
ycbD
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG1012 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
268,846  270,312
The protein
Catalyzed reaction/ biological activity
2,5-dioxopentanoate + H2O + NADP+ --> 2-oxoglutarate + 2 H+ + NADPH (according to UniProt)
Protein family
aldehyde dehydrogenase family (according to UniProt)
Cofactors
NAD+
Structure
3RHH (PDB) (from from Bacillus halodurans C-125 complexed with NADP, 36% identity, 69% similarity)
P42236 (AlphaFold)
Paralogous protein(s)
DhaS, RocA, IolA, YwdH, GabD, YfmT, AldX, AldY, GbsA, PutC
Expression and Regulation
Operons
Genes
ycbC-ycbD-ycbE-ycbF-ycbG-ycbH-ycbJ
Description
PubMed
Regulation
induced by D-glucarate/galactarate (YcbG) PubMed
Regulatory mechanism
YcbG: repression, PubMed, in ycbG regulon
AbrB: repression, PubMed, in abrB regulon
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ycbC→ycbJ

2025-03-10 23:53:20

ghost

122

a8e395a36da4d417bafa3e16f332fbbf2dcf2e61

24EBFC92FB6A93BD115AC81FF68694FB539EE76E

Biological materials
Mutant
BKE02470 (ycbD::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCCCATTGCCCCTTTCG,  downstream forward: _UP4_TAATGGTGCTGGAAAGAGGC
BKK02470 (ycbD::kan  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGCCCATTGCCCCTTTCG,  downstream forward: _UP4_TAATGGTGCTGGAAAGAGGC
References
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5B66ADB81AB141982F187B1C5E3A9346AA064DE2

Page visits: 2229

Time of last update: 2025-04-02 19:07:44

Author of last update: Melvin.boenninger