RNA degradosome

Components of the RNA degradosome

• RNase Y: ssRNA endonuclease
• RNase J1: 5'-3' exonuclease, does also have endonuclease activity
• polynucleotide phosphorylase: 3'-5' exonuclease
• RNase J2: ssRNA endonuclease, may also have exonuclease activity
• CshA
• enolase
• phosphofructokinase

Related pages

• RNases
• DEAD-box RNA helicases

Reviews on the B. subtilis RNA degradosome

Lehnik-Habrink M, Lewis RJ, Mäder U, Stülke J    
RNA degradation in Bacillus subtilis: an interplay of
essential endo- and exoribonucleases. 
Mol Microbiol.: 2012, 84(6) 1005-1017. 
PubMed:22568516

General reviews on the RNA degradosome

Additional reviews: PubMed

Zbigniew Dominski, Agamemnon J Carpousis, Béatrice Clouet-d'Orval
Emergence of the β-CASP ribonucleases: highly conserved and ubiquitous metallo-enzymes involved in messenger RNA maturation and degradation.
Biochim Biophys Acta: 2013, 1829(6-7);532-51
[PubMed:23403287] [WorldCat.org] [DOI] (P p)

Maria W Górna, Agamemnon J Carpousis, Ben F Luisi
From conformational chaos to robust regulation: the structure and function of the multi-enzyme RNA degradosome.
Q Rev Biophys: 2012, 45(2);105-45
[PubMed:22169164] [WorldCat.org] [DOI] (I p)

Vladimir R Kaberdin, Sue Lin-Chao
Unraveling new roles for minor components of the E. coli RNA degradosome.
RNA Biol: 2009, 6(4);402-5
[PubMed:19667755] [WorldCat.org] [DOI] (I p)

Agamemnon J Carpousis
The RNA degradosome of Escherichia coli: an mRNA-degrading machine assembled on RNase E.
Annu Rev Microbiol: 2007, 61;71-87
[PubMed:17447862] [WorldCat.org] [DOI] (P p)

Maria Jose Marcaida, Mark A DePristo, Vidya Chandran, Agamemnon J Carpousis, Ben F Luisi
The RNA degradosome: life in the fast lane of adaptive molecular evolution.
Trends Biochem Sci: 2006, 31(7);359-65
[PubMed:16766188] [WorldCat.org] [DOI] (P p)

A J Carpousis
The Escherichia coli RNA degradosome: structure, function and relationship in other ribonucleolytic multienzyme complexes.
Biochem Soc Trans: 2002, 30(2);150-5
[PubMed:12035760] [WorldCat.org] (P p)