Difference between revisions of "ComK"
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* '''Modification:''' | * '''Modification:''' | ||
| + | ** phosphorylated on Arg-65, Arg-157, Arg-161, Arg-165, Arg-186, and Arg-191 {{PubMed|22517742}} | ||
* '''Cofactor(s):''' | * '''Cofactor(s):''' | ||
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==Original Publications== | ==Original Publications== | ||
'''Additional publications:''' {{PubMed|22412392}} | '''Additional publications:''' {{PubMed|22412392}} | ||
| − | <pubmed>8878039,11849533,17569828,9335269,8016067,17493123,17560370,12586407,11814663,9108277,9890793,9585513,15819619,10908654,9000055,7783616,7746142,8830686,12586407, 10447896, 12028382, 8016067, 10361283, 11703662, 12107147, 17581123, 8016066 17493123,16391071,16436435 12270822 15598897 20300532 12761164 12036071 21085679 </pubmed> | + | <pubmed>8878039,11849533,17569828,9335269,8016067,17493123,17560370,12586407,11814663,9108277,9890793,9585513,15819619,10908654,9000055,7783616,7746142,8830686,12586407, 10447896, 12028382, 8016067, 10361283, 11703662, 12107147, 17581123, 8016066 17493123,16391071,16436435 12270822 15598897 20300532 12761164 12036071 21085679 22517742</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 14:22, 21 April 2012
- Description: competence transcription factor (CTF)
| Gene name | comK |
| Synonyms | |
| Essential | no |
| Product | competence transcription factor (CTF) |
| Function | regulation of competence and DNA uptake |
| Interactions involving this protein in SubtInteract: ComK | |
| Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation), Protein secretion | |
| MW, pI | 22 kDa, 7.669 |
| Gene length, protein length | 576 bp, 192 aa |
| Immediate neighbours | yhzC, yhxD |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
genetic competence, transcription factors and their control, phosphoproteins
This gene is a member of the following regulons
AbrB regulon, CodY regulon, ComK regulon, DegU regulon, Rok regulon, Spo0A regulon
The ComK regulon
The gene
Basic information
- Locus tag: BSU10420
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- phosphorylated on Arg-65, Arg-157, Arg-161, Arg-165, Arg-186, and Arg-191 PubMed
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P40396
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: comK PubMed
- Regulation:
- Regulatory mechanism:
Biological materials
- Mutant:
- Expression vector: for expression, purification in E. coli with N-terminal His-tag, pRSETA available in Gerth lab
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Oscar Kuipers, University of Groningen, The Netherlands Homepage
Your additional remarks
References
Reviews
Daniel Schultz, Peter G Wolynes, Eshel Ben Jacob, José N Onuchic
Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21027-34
[PubMed:19995980]
[WorldCat.org]
[DOI]
(I p)
Leendert W Hamoen, Gerard Venema, Oscar P Kuipers
Controlling competence in Bacillus subtilis: shared use of regulators.
Microbiology (Reading): 2003, 149(Pt 1);9-17
[PubMed:12576575]
[WorldCat.org]
[DOI]
(P p)
The ComK regulon
Original Publications
Additional publications: PubMed
