Difference between revisions of "AccC"
m (Reverted edits by 134.76.70.252 (talk) to last revision by Jstuelk) |
|||
| Line 108: | Line 108: | ||
* '''Operon:''' ''[[accB]]-[[accC]]-[[yqhY]]'' {{PubMed|7592499}} | * '''Operon:''' ''[[accB]]-[[accC]]-[[yqhY]]'' {{PubMed|7592499}} | ||
| − | * '''[ | + | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=accC_2530354_2531706_-1 accC] {{PubMed|22383849}} |
| + | |||
| + | * '''Sigma factor:''' | ||
* '''Regulation:''' | * '''Regulation:''' | ||
| Line 114: | Line 116: | ||
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | * '''Additional information:''' | + | * '''Additional information:''' |
=Biological materials = | =Biological materials = | ||
Revision as of 10:59, 16 April 2012
- Description: acetyl-CoA carboxylase (biotin carboxylase subunit)
| Gene name | accC |
| Synonyms | yqhX |
| Essential | yes PubMed |
| Product | acetyl-CoA carboxylase (biotin carboxylase subunit) |
| Function | production of malonyl-CoA, the substrate for fatty acid biosynthesis |
| Interactions involving this protein in SubtInteract: AccC | |
| Metabolic function and regulation of this protein in SubtiPathways: Lipid synthesis | |
| MW, pI | 49 kDa, 4.72 |
| Gene length, protein length | 1350 bp, 450 aa |
| Immediate neighbours | yqhY, accB |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
biosynthesis of lipids, essential genes
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU24340
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s): YotE
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- UniProt: P49787
- KEGG entry: [3]
Additional information
Expression and regulation
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Stephen W White, Jie Zheng, Yong-Mei Zhang, Rock
The structural biology of type II fatty acid biosynthesis.
Annu Rev Biochem: 2005, 74;791-831
[PubMed:15952903]
[WorldCat.org]
[DOI]
(P p)
Original Publications
P Marini, S J Li, D Gardiol, J E Cronan, D de Mendoza
The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fatty acid synthesis.
J Bacteriol: 1995, 177(23);7003-6
[PubMed:7592499]
[WorldCat.org]
[DOI]
(P p)
G L Waldrop, I Rayment, H M Holden
Three-dimensional structure of the biotin carboxylase subunit of acetyl-CoA carboxylase.
Biochemistry: 1994, 33(34);10249-56
[PubMed:7915138]
[WorldCat.org]
[DOI]
(P p)
