Difference between revisions of "ProB"
| Line 102: | Line 102: | ||
* '''Operon:''' ''[[proB]]-[[proA]]'' | * '''Operon:''' ''[[proB]]-[[proA]]'' | ||
| − | * '''[[Sigma factor]]:''' | + | * '''[[Sigma factor]]:''' [[SigA]] {{PubMed|21233158}} |
* '''Regulation:''' | * '''Regulation:''' | ||
| − | ** induced by proline limitation ([[T-box]]) {{PubMed| | + | ** induced by proline limitation ([[T-box]]) {{PubMed|21233158}} |
* '''Regulatory mechanism:''' | * '''Regulatory mechanism:''' | ||
| − | ** [[T-box]]: [[RNA switch]], transcriptional antitermination {{PubMed| | + | ** [[T-box]]: [[RNA switch]], transcriptional antitermination {{PubMed|21233158}} |
* '''Additional information:''' | * '''Additional information:''' | ||
| Line 132: | Line 132: | ||
=References= | =References= | ||
| − | <pubmed>19258532, 16958849, 17562291 </pubmed> | + | <pubmed>19258532, 16958849, 17562291 21233158 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 10:08, 17 January 2011
- Description: glutamate 5-kinase
| Gene name | proB |
| Synonyms | |
| Essential | no |
| Product | glutamate 5-kinase |
| Function | biosynthesis of proline |
| Metabolic function and regulation of this protein in SubtiPathways: Pro, Stress | |
| MW, pI | 39 kDa, 6.01 |
| Gene length, protein length | 1095 bp, 365 aa |
| Immediate neighbours | ykkE, proA |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
biosynthesis/ acquisition of amino acids
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU13120
Phenotypes of a mutant
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + L-glutamate = ADP + L-glutamate 5-phosphate (according to Swiss-Prot)
- Protein family: PUA domain (according to Swiss-Prot)
- Paralogous protein(s): ProJ
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity: the enzymatic activity is feedback-inhibited by proline {PubMed|16958849}}
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P39820
- KEGG entry: [2]
- E.C. number: 2.7.2.11
Additional information
Expression and regulation
- Regulatory mechanism:
- T-box: RNA switch, transcriptional antitermination PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
