AcuC

• Description: protein deacetylase for the control of AcsA activity
  
  

Gene name	acuC
Synonyms
Essential	no
Product	AcsA deacetylase
Function	control of AcsA activity
MW, pI	42 kDa, 5.062
Gene length, protein length	1161 bp, 387 aa
Immediate neighbours	acuB, motS
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU29710

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: deacetylates (and thereby activates) AcsA (together with SrtN) PubMed

• Protein family: histone deacetylase family (according to Swiss-Prot) class I histone deacetylase

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: P39067

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: acuA-acuB-acuC PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • repressed by glucose (CcpA) PubMed

• Regulatory mechanism:
  • CcpA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:
  • GP1209 (acuC::kan), available in Stülke lab
  • GP1213(srtN::cat)(acuC::kan), available in Stülke lab
• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody: