Difference between revisions of "MurF"
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=== Database entries === | === Database entries === | ||
− | * '''Structure:''' | + | * '''Structure:''' [http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=1GG4 1GG4] (from ''Escherichia coli'', 32% identity, 50% similarity) {{PubMed|11090285}} |
* '''UniProt:''' [http://www.uniprot.org/uniprot/P96613 P96613] | * '''UniProt:''' [http://www.uniprot.org/uniprot/P96613 P96613] |
Revision as of 12:01, 18 February 2010
- Description: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine synthetase
Gene name | murF |
Synonyms | ydbQ |
Essential | yes PubMed |
Product | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso- 2,6- diaminopimeloyl-D-alanyl-D-alanine synthetase |
Function | peptidoglycan precursor biosynthesis |
Metabolic function and regulation of this protein in SubtiPathways: Cell wall | |
MW, pI | 49 kDa, 5.337 |
Gene length, protein length | 1371 bp, 457 aa |
Immediate neighbours | ddl, cshA |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU04570
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine (according to Swiss-Prot)
- Protein family: murCDEF family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization: cytoplasm (according to Swiss-Prot)
Database entries
- UniProt: P96613
- KEGG entry: [2]
- E.C. number: 6.3.2.10
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Jean van Heijenoort
Lipid intermediates in the biosynthesis of bacterial peptidoglycan.
Microbiol Mol Biol Rev: 2007, 71(4);620-35
[PubMed:18063720]
[WorldCat.org]
[DOI]
(P p)