Difference between revisions of "Rok"
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| − | * '''Description:''' repressor of ''[[comK]]'' <br/><br/> | + | * '''Description:''' repressor of ''[[comK]]'', nucleoid associated protein that serves to help repress expression of A+T-rich genes, many of which appear to have been acquired by horizontal gene transfer <br/><br/> |
{| align="right" border="1" cellpadding="2" | {| align="right" border="1" cellpadding="2" | ||
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===Phenotypes of a mutant === | ===Phenotypes of a mutant === | ||
| − | + | higher excision rate of the conjugative transposon ICEBs1 {{PubMed|21085634}} | |
=== Database entries === | === Database entries === | ||
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=== Basic information/ Evolution === | === Basic information/ Evolution === | ||
| − | * '''Catalyzed reaction/ biological activity:''' | + | * '''Catalyzed reaction/ biological activity:''' binds to extended regions of the ''B. subtilis'' genome that are characterized by a high A+T content and are known or believed to have been acquired by horizontal gene transfer {{PubMed|21085634}} |
* '''Protein family:''' | * '''Protein family:''' | ||
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<pubmed>19995980 </pubmed> | <pubmed>19995980 </pubmed> | ||
==Original Publications== | ==Original Publications== | ||
| − | <pubmed>11849533,15819619,15743949,,17493123,14651647,12354229 | + | <pubmed>11849533,15819619,15743949,,17493123,14651647,12354229 21085634 </pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 09:18, 20 November 2010
- Description: repressor of comK, nucleoid associated protein that serves to help repress expression of A+T-rich genes, many of which appear to have been acquired by horizontal gene transfer
| Gene name | rok |
| Synonyms | ykuW |
| Essential | no |
| Product | transcriptional repressor |
| Function | regulation of genetic competence |
| MW, pI | 21 kDa, 9.701 |
| Gene length, protein length | 573 bp, 191 aa |
| Immediate neighbours | ykuV, yknT |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
The gene
Basic information
- Locus tag: BSU14240
Phenotypes of a mutant
higher excision rate of the conjugative transposon ICEBs1 PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: binds to extended regions of the B. subtilis genome that are characterized by a high A+T content and are known or believed to have been acquired by horizontal gene transfer PubMed
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure:
- UniProt: O34857
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: rok PubMed
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Reviews
Daniel Schultz, Peter G Wolynes, Eshel Ben Jacob, José N Onuchic
Deciding fate in adverse times: sporulation and competence in Bacillus subtilis.
Proc Natl Acad Sci U S A: 2009, 106(50);21027-34
[PubMed:19995980]
[WorldCat.org]
[DOI]
(I p)
Original Publications
