Difference between revisions of "Metabolism of signalling nucleotides"

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(Important original publications)
 
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* 2.5.4. [[Nucleotide metabolism/ other]]
 
* 2.5.4. [[Nucleotide metabolism/ other]]
 
|Related=
 
|Related=
none
+
* [[DAC domain]]
 +
* [[EAL domain]]
 +
* [[GGDEF domain]]
 
|}}
 
|}}
  
Line 15: Line 17:
 
===ppGpp synthesis and degradation===
 
===ppGpp synthesis and degradation===
 
* [[RelA]]
 
* [[RelA]]
* [[YjbM]]
+
* [[SasA]]
* [[YwaC]]
+
* [[SasB]]
  
 
===c-di-AMP synthesis===
 
===c-di-AMP synthesis===
Line 24: Line 26:
  
 
=== Control of c-di-AMP synthesis ===
 
=== Control of c-di-AMP synthesis ===
* [[CdaR]]
+
* [[CdaR]] controls [[CdaA]] activity {{PubMed|23192352}}
 
+
* [[RadA]] controls [[DisA]] activity {{PubMed|23760274}}
 
Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well {{PubMed|23192352}}
 
Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well {{PubMed|23192352}}
  
 
===c-di-AMP degradation===
 
===c-di-AMP degradation===
 
* [[GdpP]]
 
* [[GdpP]]
 +
* [[PgpH]]
 +
* [[YfkN]]
  
===c-di-GMP degradation (presence of an EAL domain)===
+
===Protein potentially involved in c-di-GMP metabolism and signalling===
* [[YkoW]]
 
* [[YkuI]]
 
* [[YuxH]]
 
  
=== c-di-GMP synthesis/ based on similarity (presence of a GGDEF domain)===
+
==== Proteins containing a [[GGDEF domain]] (potential diguanylate cyclases) ====
* [[GdpP]]
+
* [[DgcK]], has cyclase activity
* [[YdaK]]
+
* [[DgcW]], has cyclase activity, contains both a GGDEF and an [[EAL domain]]
* [[YhcK]]
+
* [[DgcP]], has cyclase activity
* [[YkoW]]
+
* [[YdaK]], no activity, degenerate [[GGDEF domain]]
* [[YtrP]] (this enzyme may be inactive due to the lack of important residues)
+
* [[GdpP]], no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain
 +
 
 +
==== Proteins containing an [[EAL domain]] (potential c-di-GMP phosphodiesterases) ====
 +
* [[PdeH]], has phosphodiesterase activity
 +
* [[YkuI]], no phosphodiesterase activity
 +
* [[DgcW]], phosphodiesterase activity not demonstrated, contains both a GGDEF and an [[EAL domain]]
  
 
=== Targets of signalling nucleotides ===
 
=== Targets of signalling nucleotides ===
 
* ppGpp targets
 
* ppGpp targets
 +
** [[DnaG]]
 
** [[GdpP]]
 
** [[GdpP]]
 
** [[Gmk]]
 
** [[Gmk]]
 
** [[GuaB]]
 
** [[GuaB]]
 
** [[HprT]]
 
** [[HprT]]
 +
** [[RbgA]]
 +
** [[Era]]
 +
** [[YnbA]]
  
 
* c-di-GMP targets
 
* c-di-GMP targets
** [[YpfA]] (contains a PilZ domain)
+
** [[DgrA]] (contains a PilZ domain)
 +
 
 +
* other c-di-GMP-binding proteins
 +
** [[YdaK]]
 +
** [[YkuI]]
 +
 
 +
* c-di-AMP targets
 +
** [[DarA]] {{PubMed|25433025}}
 +
** [[KtrC]] (binds c-di-AMP ''in vivo'') {{PubMed|23671116}}
 +
** the [[ydaO riboswitch]] {{PubMed|24141192}}
  
 
==Important original publications==
 
==Important original publications==
<pubmed>21566650 22981860 23192352 </pubmed>
+
<pubmed>21566650 22981860 23192352 23671116 23893111 24141192 24163341 25433025 25605304 26951678 22821967 28965724 </pubmed>
 +
 
 
==Important reviews==
 
==Important reviews==
<pubmed>21255104 16045609 17208514 19756011 19287449 18714086 23023210 </pubmed>
+
<pubmed>21255104 16045609 17208514 19756011 19287449 18714086 23023210 23812326 25636134 25869574,26773214 27354347
 +
    27149325</pubmed>
  
 
=Back to [[categories]]=
 
=Back to [[categories]]=

Latest revision as of 10:10, 3 October 2017

Parent categories
Neighbouring categories
Related categories

Genes in this functional category

ppGpp synthesis and degradation

c-di-AMP synthesis

Control of c-di-AMP synthesis

Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed

c-di-AMP degradation

Protein potentially involved in c-di-GMP metabolism and signalling

Proteins containing a GGDEF domain (potential diguanylate cyclases)

  • DgcK, has cyclase activity
  • DgcW, has cyclase activity, contains both a GGDEF and an EAL domain
  • DgcP, has cyclase activity
  • YdaK, no activity, degenerate GGDEF domain
  • GdpP, no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain

Proteins containing an EAL domain (potential c-di-GMP phosphodiesterases)

  • PdeH, has phosphodiesterase activity
  • YkuI, no phosphodiesterase activity
  • DgcW, phosphodiesterase activity not demonstrated, contains both a GGDEF and an EAL domain

Targets of signalling nucleotides

  • c-di-GMP targets
    • DgrA (contains a PilZ domain)
  • other c-di-GMP-binding proteins

Important original publications


Important reviews


Back to categories