Difference between revisions of "Glutamate metabolism"
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=== Transport systems === | === Transport systems === | ||
| − | * Ammonium uptake: [[NrgA|AmtB]] | + | * Ammonium uptake: [[NrgA|AmtB]] |
| − | + | * Glutamine uptake: [[GlnT]], [[GlnQ]]-([[GlnM]]-[[GlnP]])-[[GlnH]] | |
| − | * | + | * Glutamate uptake: [[YbeC]], [[GltT]] |
| − | |||
=== Metabolic enzymes=== | === Metabolic enzymes=== | ||
* Glutamine synthetase: [[GlnA]] | * Glutamine synthetase: [[GlnA]] | ||
* Glutamate synthase: [[GltA]], [[GltB]] | * Glutamate synthase: [[GltA]], [[GltB]] | ||
| − | * Glutamate | + | * Glutamate dehydrogenases: [[GudB]], [[RocG]] |
=== Regulators === | === Regulators === | ||
| − | * | + | * Key transcriptional regulators of nitrogen metabolism: [[GlnR]], [[GltC]], [[TnrA]] |
| + | * Additional transcriptional regulators: [[AhrC]], [[RocR]], [[CcpA]], [[Fur]] | ||
| + | * Control of ammonium uptake: [[NrgB|GlnK]] | ||
| − | = Relevant | + | = Relevant ''Subti''Wiki pages = |
| + | * [[Biosynthesis/ acquisition of amino acids]] | ||
| + | * [[Utilization of amino acids]] | ||
* [[TnrA regulon]] | * [[TnrA regulon]] | ||
* [[GlnR regulon]] | * [[GlnR regulon]] | ||
* [[GltC regulon]] | * [[GltC regulon]] | ||
| + | * [[Trigger enzymes]] | ||
| + | |||
| + | = Glutamate metabolism in [[SubtiPathways]]: [http://subtiwiki.uni-goettingen.de/pathways/glutamate.html Ammonium/ glutamate] = | ||
| + | |||
| + | = Additional websites = | ||
| + | * [http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE34383&submit.x=22&submit.y=9 transcriptome analysis of a ''[[rocG]] [[gudB]]'' mutant vs. wild type] | ||
= Labs studying glutamate metabolism= | = Labs studying glutamate metabolism= | ||
| Line 28: | Line 37: | ||
= Important publications = | = Important publications = | ||
| − | == Reviews == | + | ==Reviews== |
| − | <pubmed> 18086213 16458044 10231480 | + | <pubmed>18086213,17982469,16458044,10231480 22625175</pubmed> |
| + | == Important original publications == | ||
| + | <pubmed>23811508 </pubmed> | ||
Latest revision as of 10:44, 6 May 2021
Contents
Proteins involved in glutamate metabolism
Transport systems
Metabolic enzymes
Regulators
- Key transcriptional regulators of nitrogen metabolism: GlnR, GltC, TnrA
- Additional transcriptional regulators: AhrC, RocR, CcpA, Fur
- Control of ammonium uptake: GlnK
Relevant SubtiWiki pages
- Biosynthesis/ acquisition of amino acids
- Utilization of amino acids
- TnrA regulon
- GlnR regulon
- GltC regulon
- Trigger enzymes
Glutamate metabolism in SubtiPathways: Ammonium/ glutamate
Additional websites
Labs studying glutamate metabolism
- Fabian Commichau, Göttingen, Germany
- Susan Fisher, Boston
- Linc Sonenshein, Boston
- Jörg Stülke, Göttingen
Important publications
Reviews
Katrin Gunka, Fabian M Commichau
Control of glutamate homeostasis in Bacillus subtilis: a complex interplay between ammonium assimilation, glutamate biosynthesis and degradation.
Mol Microbiol: 2012, 85(2);213-24
[PubMed:22625175]
[WorldCat.org]
[DOI]
(I p)
Fabian M Commichau, Jörg Stülke
Trigger enzymes: bifunctional proteins active in metabolism and in controlling gene expression.
Mol Microbiol: 2008, 67(4);692-702
[PubMed:18086213]
[WorldCat.org]
[DOI]
(P p)
Abraham L Sonenshein
Control of key metabolic intersections in Bacillus subtilis.
Nat Rev Microbiol: 2007, 5(12);917-27
[PubMed:17982469]
[WorldCat.org]
[DOI]
(I p)
Fabian M Commichau, Karl Forchhammer, Jörg Stülke
Regulatory links between carbon and nitrogen metabolism.
Curr Opin Microbiol: 2006, 9(2);167-72
[PubMed:16458044]
[WorldCat.org]
[DOI]
(P p)
S H Fisher
Regulation of nitrogen metabolism in Bacillus subtilis: vive la différence!
Mol Microbiol: 1999, 32(2);223-32
[PubMed:10231480]
[WorldCat.org]
[DOI]
(P p)
Important original publications
Anne Krog, Tonje Marita Bjerkan Heggeset, Trond Erling Ellingsen, Trygve Brautaset
Functional characterization of key enzymes involved in L-glutamate synthesis and degradation in the thermotolerant and methylotrophic bacterium Bacillus methanolicus.
Appl Environ Microbiol: 2013, 79(17);5321-8
[PubMed:23811508]
[WorldCat.org]
[DOI]
(I p)
