MntA

• Description: manganese ABC transporter (membrane protein)
  
  

Gene name	mntA
Synonyms	ytgA
Essential	yes PubMed
Product	manganese ABC transporter (membrane protein)
Function	manganese uptake
Metabolic function and regulation of this protein in SubtiPathways: Stress
MW, pI	33 kDa, 6.162
Gene length, protein length	918 bp, 306 aa
Immediate neighbours	mntB, menC
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU30770

Phenotypes of a mutant

essential PubMed

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: bacterial solute-binding protein 9 family (according to Swiss-Prot)

• Paralogous protein(s): YcdH

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cell membrane (according to Swiss-Prot), extracellular (signal peptide) PubMed

Database entries

• Structure:

• Swiss prot entry: O34385

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: mntA-mntB-mntC-mntD PubMed

• Sigma factor:

• Regulation: repressed by Mn(2+) (MntR) PubMed
  • activated at low Mn(II) concentrations (MntR) PubMed

• Regulatory mechanism: MntR: transcription repression PubMed
  • MntR: transcription activation PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

John Helmann, Cornell University, USA Homepage

References

1. Voigt et al. (2009) Cell physiology and protein secretion of Bacillus licheniformis compared to Bacillus subtilis. J Mol Microbiol Biotechnol. 16: 53-68 PubMed
2. Que Q, Helmann JD. (2000) Manganese homeostasis in Bacillus subtilis is regulated by MntR, a bifunctional regulator related to the diphtheria toxin repressor family of proteins. Mol Microbiol. Mar;35(6): 1454-68. PubMed
3. Thomaides, H. B., Davison, E. J., Burston, L., Johnson, H., Brown, D. R., Hunt, A. C., Errington, J., and Czaplewski, L. (2007) Essential bacterial functions encoded by gene pairs. J Bacteriol 189, 591-602. PubMed
4. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed