Ugd

• Description: UDP-glucose dehydrogenase
  
  

Gene name	ywqF
Synonyms
Essential	no
Product	UDP-glucose dehydrogenase
Function	unknown
MW, pI	47 kDa, 5.03
Gene length, protein length	1320 bp, 440 aa
Immediate neighbours	ywqG, ptpZ
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + 2 H+

• Protein family: UDP-glucose/GDP-mannose dehydrogenase family (according to Swiss-Prot)

• Paralogous protein(s): TuaD, YtcA

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation on Tyr-70 by PtkA PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure:

• Swiss prot entry: P96718

• KEGG entry: BSU36230

• E.C. number: 1.1.1.22

Expression and regulation

• Operon: tkmA-ptkA-ptpZ-ywqF PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

1. Mijakovic I, Poncet S, Boël G, Mazé A, Gillet S, Decottignies P, Grangeasse C, Jamet E, Doublet P, Le Maréchal P, Deutscher J (2003) Transmembrane modulator-dependent bacterial tyrosine kinase activates UDP-glucose dehydrogenases. EMBO J 22:4709-4718. PubMed
2. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed