Difference between revisions of "Replisome"
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[[PolC]]-[[HolA]]-[[HolB]]-[[DnaX]]-[[DnaN]]-[[DnaG]]-[[DnaC]]-[[DnaI]]-[[DnaD]]-[[SsbA]]-[[DnaE]]-[[PriA]]-[[DnaB]] {{PubMed|20122408}} | [[PolC]]-[[HolA]]-[[HolB]]-[[DnaX]]-[[DnaN]]-[[DnaG]]-[[DnaC]]-[[DnaI]]-[[DnaD]]-[[SsbA]]-[[DnaE]]-[[PriA]]-[[DnaB]] {{PubMed|20122408}} | ||
| + | [[RecA]] colocalizes to the [[replisome]] in response to endogenous and exogenous DNA damage and in response to damage-independent fork arrest (formation of DNA repair centers), repair center formation depends on [[RecO]] and [[RecR]], and is facilitated by [[RecF]] and [[SsbA]] {{PubMed|24891441}} | ||
==Related pages== | ==Related pages== | ||
* [[DNA replication]] | * [[DNA replication]] | ||
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==''In vitro'' reconstitution of the replisome== | ==''In vitro'' reconstitution of the replisome== | ||
| − | <pubmed> 20122408 </pubmed> | + | <pubmed> 20122408 35635709 </pubmed> |
==Reviews== | ==Reviews== | ||
| − | <pubmed> 16036556 21675919 </pubmed> | + | <pubmed>26097470 16036556 21675919,29856930 </pubmed> |
==Other important publications== | ==Other important publications== | ||
| − | + | <pubmed> 21350489 21419346</pubmed> | |
| − | <pubmed> 21350489 </pubmed> | ||
Latest revision as of 10:54, 20 June 2022
The replisome is a protein complex that is required and sufficient for replication of both leading and lagging strands.
PolC-HolA-HolB-DnaX-DnaN-DnaG-DnaC-DnaI-DnaD-SsbA-DnaE-PriA-DnaB PubMed
RecA colocalizes to the replisome in response to endogenous and exogenous DNA damage and in response to damage-independent fork arrest (formation of DNA repair centers), repair center formation depends on RecO and RecR, and is facilitated by RecF and SsbA PubMed
Contents
Related pages
Back to Protein-protein interactions
In vitro reconstitution of the replisome
Hannah Gaimster, Charles Winterhalter, Alan Koh, Heath Murray
Visualizing the Replisome, Chromosome Breaks, and Replication Restart in Bacillus subtilis.
Methods Mol Biol: 2022, 2476;263-276
[PubMed:35635709]
[WorldCat.org]
[DOI]
(I p)
Glenn M Sanders, H Garry Dallmann, Charles S McHenry
Reconstitution of the B. subtilis replisome with 13 proteins including two distinct replicases.
Mol Cell: 2010, 37(2);273-81
[PubMed:20122408]
[WorldCat.org]
[DOI]
(I p)
Reviews
Kevin S Lang, Houra Merrikh
The Clash of Macromolecular Titans: Replication-Transcription Conflicts in Bacteria.
Annu Rev Microbiol: 2018, 72;71-88
[PubMed:29856930]
[WorldCat.org]
[DOI]
(I p)
Thomas R Beattie, Rodrigo Reyes-Lamothe
A Replisome's journey through the bacterial chromosome.
Front Microbiol: 2015, 6;562
[PubMed:26097470]
[WorldCat.org]
[DOI]
(P e)
Charles S McHenry
DNA replicases from a bacterial perspective.
Annu Rev Biochem: 2011, 80;403-36
[PubMed:21675919]
[WorldCat.org]
[DOI]
(I p)
Patrick M Schaeffer, Madeleine J Headlam, Nicholas E Dixon
Protein--protein interactions in the eubacterial replisome.
IUBMB Life: 2005, 57(1);5-12
[PubMed:16036556]
[WorldCat.org]
[DOI]
(P p)
Other important publications
Masayuki Su'etsugu, Jeff Errington
The replicase sliding clamp dynamically accumulates behind progressing replication forks in Bacillus subtilis cells.
Mol Cell: 2011, 41(6);720-32
[PubMed:21419346]
[WorldCat.org]
[DOI]
(I p)
Houra Merrikh, Cristina Machón, William H Grainger, Alan D Grossman, Panos Soultanas
Co-directional replication-transcription conflicts lead to replication restart.
Nature: 2011, 470(7335);554-7
[PubMed:21350489]
[WorldCat.org]
[DOI]
(I p)
