recR

recR
168

required for the formation of RecA DNA repair centers

Locus
BSU_00210
Molecular weight
21.83 kDa
Isoelectric point
5.3
Protein length
198 aaSequenceBlast
Gene length
597 bpSequenceBlast
Function
DNA repair/ recombination
Product
formation of RecA DNA repair centers
Essential
no
Synonyms
recR, recM
Outlinks
BsubCyc SubtiList UniProt STRING Genoscapist PaperBLAST

Genomic Context

List of homologs in different organisms, belongs to COG0353 (Galperin et al., 2021)

Gene
Coordinates
28,867 → 29,463
Phenotypes of a mutant
drastically reduced survival of mature dormant spores after exposure to ultrahigh vacuum desiccation and ionizing radiation that induce single strand (ss) DNA nicks and double-strand breaks (DSBs) PubMed
The protein
Catalyzed reaction/ biological activity
required for the formation of RecA DNA repair centers (together with RecO) PubMed
Protein family
RecR family (single member, according to UniProt)
Domains
TOPRIM domain (aa 80-175) PubMed
Structure
3VDP (PDB) (from Caldanaerobacter subterraneus subsp. tengcongensis MB4, 64.3% identity) PubMed
2V1C (PDB) (the RecR-RecO complex from Deinococcus radiodurans, RecR: 52% identity, 78% similarity, RecO: 30%/ 58%)  PubMed
P24277 (AlphaFold)
Localization
cytoplasm (homogeneous) PubMed
Expression and Regulation
Operons
Genes
dnaX-yaaK-recR-yaaL-bofA
Description
PubMed
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dnaX→bofA

2025-03-09 08:54:22

Jstuelk

151

1a32cdecddaee24171f48459041fdcb062bafc36

7EC4B7D4D9D0E5E8848420FD5562059E4207233C

Additional information
the mRNA is very stable (> 15 min) PubMed
Biological materials
Mutant
BKE00210 (ΔrecR::erm  trpC2) available at BGSC,  PubMed, upstream reverse: _UP1_CATGTTCTTTTATCCCCCTA,  downstream forward: _UP4_TTGTAAGGAGGAAAAAGCGA
BKK00210 (ΔrecR::kan  trpC2) available at BGSC and in Jörg Stülke's lab,  PubMed, upstream reverse: _UP1_CATGTTCTTTTATCCCCCTA,  downstream forward: _UP4_TTGTAAGGAGGAAAAAGCGA
References
Reviews
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Original Publications
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BEBAF1EB53EBB3E7558BB5FE73C418B50000FA29

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Time of last update: 2025-04-02 12:27:12

Author of last update: Jstuelk