Difference between revisions of "Biofilm formation"
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| − | Biofilms are the result of the multicellular lifestyle of ''B. subtilis''. They are characterized by the formation of a matrix polysaccharide and an amyloid-like protein, [[TasA]]. Correction of ''[[sfp]]'', ''[[epsC]]'','' [[swrAA]]'', and ''[[degQ]]'' as well as introduction of ''rapP'' from a plasmid present in NCIB3610 results in biofilm formation in ''B. subtilis'' 168 {{PubMed|21278284}}. | + | Biofilms are the result of the multicellular lifestyle of ''B. subtilis''. They are characterized by the formation of a matrix polysaccharide (poly-N-acetyl glucosamine as a major polysaccharide {{PubMed|26078454}}) and an amyloid-like protein, [[TasA]]. Correction of ''[[sfp]]'', ''[[epsC]]'','' [[swrAA]]'', and ''[[degQ]]'' as well as introduction of ''rapP'' from a plasmid present in NCIB3610 results in biofilm formation in ''B. subtilis'' 168 {{PubMed|21278284}}. |
| Line 8: | Line 8: | ||
|Neighbours= | |Neighbours= | ||
* 4.1.1. [[Motility and chemotaxis]] | * 4.1.1. [[Motility and chemotaxis]] | ||
| − | * 4.1.2. [[Biofilm formation]] | + | * 4.1.2. [[Swarming]] |
| − | * 4.1. | + | * 4.1.3. [[Sliding]] |
| + | * 4.1.4. [[Biofilm formation]] | ||
| + | * 4.1.5. [[Genetic competence]] | ||
|Related= | |Related= | ||
| − | + | [[SinR regulon]] | |
|}} | |}} | ||
| Line 19: | Line 21: | ||
==Labs working on biofilm formation== | ==Labs working on biofilm formation== | ||
| + | * [[Roberto Grau]] | ||
* [[Daniel Kearns]] | * [[Daniel Kearns]] | ||
| + | * [[Roberto Kolter]] | ||
| + | * [[Akos T Kovacs]] | ||
* [[Oscar Kuipers]] | * [[Oscar Kuipers]] | ||
* [[Beth Lazazzera]] | * [[Beth Lazazzera]] | ||
* [[Richard Losick]] | * [[Richard Losick]] | ||
| + | * [[Eric Raspaud]] | ||
* [[Nicola Stanley-Wall]] | * [[Nicola Stanley-Wall]] | ||
| + | * [[Jörg Stülke]] | ||
==Key genes and operons involved in biofilm formation== | ==Key genes and operons involved in biofilm formation== | ||
| − | * matrix polysaccharide synthesis: | + | * matrix polysaccharide synthesis {{PubMed|26078454}}: |
** ''[[epsA]]-[[epsB]]-[[epsC]]-[[epsD]]-[[epsE]]-[[epsF]]-[[epsG]]-[[epsH]]-[[epsI]]-[[epsJ]]-[[epsK]]-[[epsL]]-[[epsM]]-[[epsN]]-[[epsO]]'' | ** ''[[epsA]]-[[epsB]]-[[epsC]]-[[epsD]]-[[epsE]]-[[epsF]]-[[epsG]]-[[epsH]]-[[epsI]]-[[epsJ]]-[[epsK]]-[[epsL]]-[[epsM]]-[[epsN]]-[[epsO]]'' | ||
| − | * amyloid protein synthesis | + | **'' [[galE]]'' |
| − | ** ''[[ | + | * amyloid protein synthesis, secretion and assembly |
| + | ** ''[[tapA]]-[[sipW]]-[[tasA]]'' | ||
| + | * repellent surface layer | ||
| + | ** ''[[bslA]]'' | ||
* regulation | * regulation | ||
** [[SlrR]] | ** [[SlrR]] | ||
| Line 35: | Line 45: | ||
** [[SinR]] | ** [[SinR]] | ||
** [[SinI]] | ** [[SinI]] | ||
| + | ** [[KinC]] | ||
| + | ** [[KinD]] | ||
| + | ** [[Spo0A]] | ||
** [[PtkA]] | ** [[PtkA]] | ||
** [[TkmA]] | ** [[TkmA]] | ||
| Line 40: | Line 53: | ||
** [[DegU]] | ** [[DegU]] | ||
** [[DegQ]] | ** [[DegQ]] | ||
| − | ** [[ | + | ** [[YmdB]] |
| − | * | + | ** [[FtsH]] |
| − | ** [[ | + | ** [[Veg]] |
| + | ** [[MstX]] | ||
| + | ** [[YugO]] | ||
| + | |||
* other proteins required for biofilm formation | * other proteins required for biofilm formation | ||
| − | ** [[Sfp]] | + | ** [[AmpS]] |
| + | ** [[FloT]] | ||
| + | ** [[LuxS]] | ||
| + | ** [[RemA]] | ||
| + | ** [[RemB]] | ||
| + | ** [[Rny]] | ||
| + | ** [[Sfp/1]] | ||
| + | ** [[Sfp/2]] | ||
** [[SpeA]] | ** [[SpeA]] | ||
| + | ** [[SpeD]] | ||
** [[SwrAA]] | ** [[SwrAA]] | ||
| + | ** [[YisP]] | ||
| + | ** [[YlbF]] | ||
** [[YmcA]] | ** [[YmcA]] | ||
| + | ** [[YvcA]] | ||
| + | ** [[YwcC]] | ||
** [[YxaB]] | ** [[YxaB]] | ||
| + | |||
| + | * other proteins required for efficient pellicle biofilm formation (mutant is out-competed by wild type) | ||
| + | ** [[Hag]] | ||
| + | ** [[FlgE]] | ||
| + | ** [[FliF]] | ||
| + | ** [[MotA]] | ||
| + | ** [[SigD]] | ||
| + | ** [[CheA]] | ||
| + | ** [[CheY]] | ||
| + | ** [[CheD]] | ||
| + | ** [[CheV]] | ||
| + | ** [[HemAT]] | ||
==Important original publications== | ==Important original publications== | ||
| − | <pubmed> 21267464 21278284 16091050 </pubmed> | + | <pubmed> 26122431, 26588577, 26152584, 26078454 25870300 26060272 25825426 23271809, 23300252 21267464 21278284 16091050 22232655 22371091 23341623 23406351 25768534 23012477,22934631 23517761 23569226 23564171 25035996 23637960 23645570 24256735 25422306 25680358 25713360 25894589 26200335 26873313 30297741 28462927,31113899 |
| + | </pubmed> | ||
==Key reviews== | ==Key reviews== | ||
| − | <pubmed> | + | <pubmed>16787201,24771632, 9891794,19054118,20890834,21109420,20519345,18381896 22024380 20735481 23353768 23791621 23927648 24384602 24909922 26104716 24988880 24608334 25907113,30218468</pubmed> |
| − | + | ||
=Back to [[categories]]= | =Back to [[categories]]= | ||
Latest revision as of 08:49, 24 May 2019
Biofilms are the result of the multicellular lifestyle of B. subtilis. They are characterized by the formation of a matrix polysaccharide (poly-N-acetyl glucosamine as a major polysaccharide PubMed) and an amyloid-like protein, TasA. Correction of sfp, epsC, swrAA, and degQ as well as introduction of rapP from a plasmid present in NCIB3610 results in biofilm formation in B. subtilis 168 PubMed.
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Contents
Biofilm formation in SubtiPathways
Labs working on biofilm formation
- Roberto Grau
- Daniel Kearns
- Roberto Kolter
- Akos T Kovacs
- Oscar Kuipers
- Beth Lazazzera
- Richard Losick
- Eric Raspaud
- Nicola Stanley-Wall
- Jörg Stülke
Key genes and operons involved in biofilm formation
- matrix polysaccharide synthesis PubMed:
- amyloid protein synthesis, secretion and assembly
- repellent surface layer
- regulation
- other proteins required for biofilm formation
- other proteins required for efficient pellicle biofilm formation (mutant is out-competed by wild type)
Important original publications
Key reviews
