Difference between revisions of "Metabolism of signalling nucleotides"
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|Related= | |Related= | ||
* [[DAC domain]] | * [[DAC domain]] | ||
+ | * [[EAL domain]] | ||
+ | * [[GGDEF domain]] | ||
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===Protein potentially involved in c-di-GMP metabolism and signalling=== | ===Protein potentially involved in c-di-GMP metabolism and signalling=== | ||
− | ==== Proteins containing a GGDEF domain (potential diguanylate cyclases) ==== | + | ==== Proteins containing a [[GGDEF domain]] (potential diguanylate cyclases) ==== |
* [[DgcK]], has cyclase activity | * [[DgcK]], has cyclase activity | ||
− | * [[DgcW]], has cyclase activity, contains both a GGDEF and an EAL domain | + | * [[DgcW]], has cyclase activity, contains both a GGDEF and an [[EAL domain]] |
* [[DgcP]], has cyclase activity | * [[DgcP]], has cyclase activity | ||
− | * [[YdaK]], no activity, | + | * [[YdaK]], no activity, degenerate [[GGDEF domain]] |
− | * [[GdpP]], no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), | + | * [[GdpP]], no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain |
− | ==== Proteins containing an EAL domain (potential c-di-GMP phosphodiesterases) ==== | + | ==== Proteins containing an [[EAL domain]] (potential c-di-GMP phosphodiesterases) ==== |
* [[PdeH]], has phosphodiesterase activity | * [[PdeH]], has phosphodiesterase activity | ||
* [[YkuI]], no phosphodiesterase activity | * [[YkuI]], no phosphodiesterase activity | ||
− | * [[DgcW]], phosphodiesterase activity not demonstrated, contains both a GGDEF and an EAL domain | + | * [[DgcW]], phosphodiesterase activity not demonstrated, contains both a GGDEF and an [[EAL domain]] |
=== Targets of signalling nucleotides === | === Targets of signalling nucleotides === |
Revision as of 12:12, 5 July 2016
Parent categories |
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Neighbouring categories | |
Related categories | |
Contents
- 1 Genes in this functional category
- 2 Important original publications
- 3 Important reviews
- 4 Back to categories
Genes in this functional category
ppGpp synthesis and degradation
c-di-AMP synthesis
Control of c-di-AMP synthesis
Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed
c-di-AMP degradation
Protein potentially involved in c-di-GMP metabolism and signalling
Proteins containing a GGDEF domain (potential diguanylate cyclases)
- DgcK, has cyclase activity
- DgcW, has cyclase activity, contains both a GGDEF and an EAL domain
- DgcP, has cyclase activity
- YdaK, no activity, degenerate GGDEF domain
- GdpP, no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain
Proteins containing an EAL domain (potential c-di-GMP phosphodiesterases)
- PdeH, has phosphodiesterase activity
- YkuI, no phosphodiesterase activity
- DgcW, phosphodiesterase activity not demonstrated, contains both a GGDEF and an EAL domain
Targets of signalling nucleotides
- c-di-GMP targets
- DgrA (contains a PilZ domain)
Important original publications
Rebecca M Corrigan, Lauren E Bellows, Alison Wood, Angelika Gründling
ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria.
Proc Natl Acad Sci U S A: 2016, 113(12);E1710-9
[PubMed:26951678]
[WorldCat.org]
[DOI]
(I p)
Anthony O Gaca, Cristina Colomer-Winter, José A Lemos
Many means to a common end: the intricacies of (p)ppGpp metabolism and its control of bacterial homeostasis.
J Bacteriol: 2015, 197(7);1146-56
[PubMed:25605304]
[WorldCat.org]
[DOI]
(I p)
Jan Gundlach, Achim Dickmanns, Kathrin Schröder-Tittmann, Piotr Neumann, Jan Kaesler, Jan Kampf, Christina Herzberg, Elke Hammer, Frank Schwede, Volkhard Kaever, Kai Tittmann, Jörg Stülke, Ralf Ficner
Identification, characterization, and structure analysis of the cyclic di-AMP-binding PII-like signal transduction protein DarA.
J Biol Chem: 2015, 290(5);3069-80
[PubMed:25433025]
[WorldCat.org]
[DOI]
(I p)
Allison Kriel, Shaun R Brinsmade, Jessica L Tse, Ashley K Tehranchi, Alycia N Bittner, Abraham L Sonenshein, Jue D Wang
GTP dysregulation in Bacillus subtilis cells lacking (p)ppGpp results in phenotypic amino acid auxotrophy and failure to adapt to nutrient downshift and regulate biosynthesis genes.
J Bacteriol: 2014, 196(1);189-201
[PubMed:24163341]
[WorldCat.org]
[DOI]
(I p)
James W Nelson, Narasimhan Sudarsan, Kazuhiro Furukawa, Zasha Weinberg, Joy X Wang, Ronald R Breaker
Riboswitches in eubacteria sense the second messenger c-di-AMP.
Nat Chem Biol: 2013, 9(12);834-9
[PubMed:24141192]
[WorldCat.org]
[DOI]
(I p)
Xiaohui Gao, Sampriti Mukherjee, Paige M Matthews, Loubna A Hammad, Daniel B Kearns, Charles E Dann
Functional characterization of core components of the Bacillus subtilis cyclic-di-GMP signaling pathway.
J Bacteriol: 2013, 195(21);4782-92
[PubMed:23893111]
[WorldCat.org]
[DOI]
(I p)
Rebecca M Corrigan, Ivan Campeotto, Tharshika Jeganathan, Kevin G Roelofs, Vincent T Lee, Angelika Gründling
Systematic identification of conserved bacterial c-di-AMP receptor proteins.
Proc Natl Acad Sci U S A: 2013, 110(22);9084-9
[PubMed:23671116]
[WorldCat.org]
[DOI]
(I p)
Felix M P Mehne, Katrin Gunka, Hinnerk Eilers, Christina Herzberg, Volkhard Kaever, Jörg Stülke
Cyclic di-AMP homeostasis in bacillus subtilis: both lack and high level accumulation of the nucleotide are detrimental for cell growth.
J Biol Chem: 2013, 288(3);2004-17
[PubMed:23192352]
[WorldCat.org]
[DOI]
(I p)
Allison Kriel, Alycia N Bittner, Sok Ho Kim, Kuanqing Liu, Ashley K Tehranchi, Winnie Y Zou, Samantha Rendon, Rui Chen, Benjamin P Tu, Jue D Wang
Direct regulation of GTP homeostasis by (p)ppGpp: a critical component of viability and stress resistance.
Mol Cell: 2012, 48(2);231-41
[PubMed:22981860]
[WorldCat.org]
[DOI]
(I p)
Yaara Oppenheimer-Shaanan, Ezequiel Wexselblatt, Jehoshua Katzhendler, Eylon Yavin, Sigal Ben-Yehuda
c-di-AMP reports DNA integrity during sporulation in Bacillus subtilis.
EMBO Rep: 2011, 12(6);594-601
[PubMed:21566650]
[WorldCat.org]
[DOI]
(I p)
Important reviews