Difference between revisions of "Metabolism of signalling nucleotides"

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(Important reviews)
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|Related=
 
|Related=
 
* [[DAC domain]]  
 
* [[DAC domain]]  
 +
* [[EAL domain]]
 +
* [[GGDEF domain]]
 
|}}
 
|}}
  
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===Protein potentially involved in c-di-GMP metabolism and signalling===
 
===Protein potentially involved in c-di-GMP metabolism and signalling===
  
==== Proteins containing a GGDEF domain (potential diguanylate cyclases) ====
+
==== Proteins containing a [[GGDEF domain]] (potential diguanylate cyclases) ====
 
* [[DgcK]], has cyclase activity
 
* [[DgcK]], has cyclase activity
* [[DgcW]], has cyclase activity, contains both a GGDEF and an EAL domain
+
* [[DgcW]], has cyclase activity, contains both a GGDEF and an [[EAL domain]]
 
* [[DgcP]], has cyclase activity
 
* [[DgcP]], has cyclase activity
* [[YdaK]], no activity, modified GGDEF domain
+
* [[YdaK]], no activity, degenerate [[GGDEF domain]]
* [[GdpP]], no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), modified GGDEF domain
+
* [[GdpP]], no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain
  
==== Proteins containing an EAL domain (potential c-di-GMP phosphodiesterases) ====
+
==== Proteins containing an [[EAL domain]] (potential c-di-GMP phosphodiesterases) ====
 
* [[PdeH]], has phosphodiesterase activity
 
* [[PdeH]], has phosphodiesterase activity
 
* [[YkuI]], no phosphodiesterase activity
 
* [[YkuI]], no phosphodiesterase activity
* [[DgcW]], phosphodiesterase activity not demonstrated, contains both a GGDEF and an EAL domain
+
* [[DgcW]], phosphodiesterase activity not demonstrated, contains both a GGDEF and an [[EAL domain]]
  
 
=== Targets of signalling nucleotides ===
 
=== Targets of signalling nucleotides ===

Revision as of 12:12, 5 July 2016

Parent categories
Neighbouring categories
Related categories

Genes in this functional category

ppGpp synthesis and degradation

c-di-AMP synthesis

Control of c-di-AMP synthesis

Note that c-di-AMP is essential for the growth of B. subtilis, but accumulation of the nucleotide is detrimental as well PubMed

c-di-AMP degradation

Protein potentially involved in c-di-GMP metabolism and signalling

Proteins containing a GGDEF domain (potential diguanylate cyclases)

  • DgcK, has cyclase activity
  • DgcW, has cyclase activity, contains both a GGDEF and an EAL domain
  • DgcP, has cyclase activity
  • YdaK, no activity, degenerate GGDEF domain
  • GdpP, no diguanylate cyclase activity, is c-di-AMP specific phosphodiesterase (see above), degenerate GGDEF domain

Proteins containing an EAL domain (potential c-di-GMP phosphodiesterases)

  • PdeH, has phosphodiesterase activity
  • YkuI, no phosphodiesterase activity
  • DgcW, phosphodiesterase activity not demonstrated, contains both a GGDEF and an EAL domain

Targets of signalling nucleotides

  • c-di-GMP targets
    • DgrA (contains a PilZ domain)
  • other c-di-GMP-binding proteins

Important original publications


Important reviews


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