Difference between revisions of "BmrC"

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(Expression and regulation)
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=Expression and regulation=
 
=Expression and regulation=
  
* '''Operon:'''  
+
* '''Operon:''' ''[[bmrB]]-[[bmrC]]-[[bmrD]]'' {{PubMed|25217586}}
  
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yheI_1045318_1047075_1 bmrC] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yheI_1045318_1047075_1 bmrC] {{PubMed|22383849}}
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* '''Regulation:'''  
 
* '''Regulation:'''  
** induced in response to antibiotics that target protein synthesis {{PubMed|25217586}}
+
** induced in response to antibiotics that target protein synthesis ([[BmrB]]) {{PubMed|25217586}}
 +
** ''[[bmrC]]-[[bmrD]]'' expression only occurs during the late-exponential and stationary growth stages, irrespective of the timing of the antibiotic challenge ([[AbrB]]) {{PubMed|25217586}}
  
 
* '''Regulatory mechanism:'''  
 
* '''Regulatory mechanism:'''  
 +
** [[AbrB]]: transcription repression {{PubMed|25217586}}
 +
** [[BmrB]]: transcriptional attenuation {{PubMed|25217586}}
  
 
* '''Additional information:'''
 
* '''Additional information:'''

Revision as of 08:42, 19 September 2014

  • Description: multidrug ABC transporter (ATP-binding protein), also involved in the signalling pathway to activate KinA at the onset of sporulation

Gene name bmrC
Synonyms yheI
Essential no
Product multidrug ABC transporter (ATP-binding protein)
Function multiple antibiotic resistance
Gene expression levels in SubtiExpress: bmrC
Interactions involving this protein in SubtInteract: BmrC
MW, pI 64 kDa, 6.252
Gene length, protein length 1755 bp, 585 aa
Immediate neighbours yheJ, bmrD
Sequences Protein DNA DNA_with_flanks
Genetic context
YheI context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
BmrC expression.png















Categories containing this gene/protein

ABC transporters, resistance against toxins/ antibiotics, membrane proteins, sporulation proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU09710

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: has both a membrane-spanning and an ATP-binding domain PubMed
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
    • induced in response to antibiotics that target protein synthesis (BmrB) PubMed
    • bmrC-bmrD expression only occurs during the late-exponential and stationary growth stages, irrespective of the timing of the antibiotic challenge (AbrB) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References