YokJ

• Description: putative antitoxin
  
  

Gene name	yokJ
Synonyms
Essential	no
Product	putative antitoxin
Function	inhibition of the cytotoxic activity of YokI
Gene expression levels in SubtiExpress: yokJ
Interactions involving this protein in SubtInteract: YokJ
MW, pI	18 kDa, 4.134
Gene length, protein length	495 bp, 165 aa
Immediate neighbours	yokK, yokI
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

toxins, antitoxins and immunity against toxins, SP-beta prophage

This gene is a member of the following regulons

AbrB regulon

The gene

Basic information

• Locus tag: BSU21570

Database entries

• BsubCyc: BSU21570

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:
  • YokI-YokJ PubMed

• Localization:

Database entries

• BsubCyc: BSU21570

• Structure:

• UniProt: O31997

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon: yokI-yokJ-yokK-yokL PubMed

• Expression browser: yokJ PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:
  • AbrB: transcription repression PubMed

• Additional information:
  • number of protein molecules per cell (minimal medium with glucose and ammonium): 400 PubMed

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Laura E Holberger, Fernando Garza-Sánchez, James Lamoureux, David A Low, Christopher S Hayes
A novel family of toxin/antitoxin proteins in Bacillus species.
FEBS Lett: 2012, 586(2);132-6
[PubMed:22200572] [WorldCat.org] [DOI] (I p)

Onuma Chumsakul, Hiroki Takahashi, Taku Oshima, Takahiro Hishimoto, Shigehiko Kanaya, Naotake Ogasawara, Shu Ishikawa
Genome-wide binding profiles of the Bacillus subtilis transition state regulator AbrB and its homolog Abh reveals their interactive role in transcriptional regulation.
Nucleic Acids Res: 2011, 39(2);414-28
[PubMed:20817675] [WorldCat.org] [DOI] (I p)