Difference between revisions of "DctS"
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= [[Categories]] containing this gene/protein = | = [[Categories]] containing this gene/protein = | ||
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=== Additional information=== | === Additional information=== | ||
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=The protein= | =The protein= | ||
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* '''Kinetic information:''' | * '''Kinetic information:''' | ||
| − | * '''Domains:''' two transmembrane segments, C-terminal histidine phosphotransferase domain | + | * '''[[Domains]]:''' two transmembrane segments, C-terminal histidine phosphotransferase domain |
* '''Modification:''' autophosphorylation on a His residue | * '''Modification:''' autophosphorylation on a His residue | ||
| − | * ''' | + | * '''Cofactors:''' |
* '''Effectors of protein activity:''' | * '''Effectors of protein activity:''' | ||
| + | ** [[DctB]] and [[DctP]] act as co-sensors with [[DctS]] {{PubMed|24375102}} | ||
* '''[[SubtInteract|Interactions]]:''' | * '''[[SubtInteract|Interactions]]:''' | ||
** [[DctS]]-[[DctR]] | ** [[DctS]]-[[DctR]] | ||
| + | ** [[DctB]]-[[DctS]]-[[DctP]], sensing complex {{PubMed|24375102}} | ||
* '''[[Localization]]:''' cell membrane (according to Swiss-Prot) | * '''[[Localization]]:''' cell membrane (according to Swiss-Prot) | ||
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=dctS_497768_499375_1 dctS] {{PubMed|22383849}} | * '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=dctS_497768_499375_1 dctS] {{PubMed|22383849}} | ||
| − | * '''Sigma factor:''' | + | * '''[[Sigma factor]]:''' |
* '''Regulation:''' | * '''Regulation:''' | ||
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=References= | =References= | ||
| − | <pubmed>10094672,10708364 , </pubmed> | + | <pubmed>10094672,10708364 , 24375102</pubmed> |
[[Category:Protein-coding genes]] | [[Category:Protein-coding genes]] | ||
Revision as of 16:28, 2 January 2014
- Description: two-component sensor kinase, regulation of the dctS-dctR-dctP operon
| Gene name | dctS |
| Synonyms | ydbF |
| Essential | no |
| Product | two-component sensor kinase |
| Function | regulation of the dctS-dctR-dctP operon |
| Gene expression levels in SubtiExpress: dctS | |
| Interactions involving this protein in SubtInteract: DctS | |
| Metabolic function and regulation of this protein in SubtiPathways: Central C-metabolism | |
| MW, pI | 59 kDa, 6.198 |
| Gene length, protein length | 1605 bp, 535 aa |
| Immediate neighbours | dctB, dctR |
| Sequences | Protein DNA DNA_with_flanks |
Genetic context 
This image was kindly provided by SubtiList
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Expression at a glance PubMed
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Contents
Categories containing this gene/protein
utilization of specific carbon sources, protein modification, transcription factors and their control, membrane proteins, phosphoproteins
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU04450
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: autophosphorylation, phosphorylation of DctR
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain
- Modification: autophosphorylation on a His residue
- Cofactors:
- Localization: cell membrane (according to Swiss-Prot)
Database entries
- Structure:
- UniProt: P96601
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant: GP225 (dctS::cat), available in Jörg Stülke's lab
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Sabrina Graf, Dominik Schmieden, Karolin Tschauner, Sabine Hunke, Gottfried Unden
The sensor kinase DctS forms a tripartite sensor unit with DctB and DctA for sensing C4-dicarboxylates in Bacillus subtilis.
J Bacteriol: 2014, 196(5);1084-93
[PubMed:24375102]
[WorldCat.org]
[DOI]
(I p)
Kei Asai, Sang-Hoon Baik, Yasuhiro Kasahara, Shigeki Moriya, Naotake Ogasawara
Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
Microbiology (Reading): 2000, 146 ( Pt 2);263-271
[PubMed:10708364]
[WorldCat.org]
[DOI]
(P p)
C Fabret, V A Feher, J A Hoch
Two-component signal transduction in Bacillus subtilis: how one organism sees its world.
J Bacteriol: 1999, 181(7);1975-83
[PubMed:10094672]
[WorldCat.org]
[DOI]
(P p)
